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XING Guo-Gang

XING Guo-Gang(邢国刚)Ph.D.

Professor, vice director

Neuroscience Research Institute, Peking University

Department of Neurobiology, School of Basic Medical Sciences, Peking University

Key Laboratory for Neuroscience, Ministry of Education of China & National Health Commission of China

Laboratory for Molecular Studies on Chronic Pain

Phone: 86 (0)10 82805842

Email: ggxing@bjmu.edu.cn

 

Educational and Professional Experience

2013 - present Professor, Department of Neurobiology, School of Basic Medical Sciences, Peking University

2004 - 2013 Associate Professor, Department of Neurobiology, School of Basic Medical Sciences, Peking University

2004 - 2006 Visiting scholar, Sanford-Burnham Medical Research Institute and Department of Physiology, University of Wisconsin-Madison

2003 - 2004 Lecturer, Department of Neurobiology, School of Basic Medical Sciences, Peking University

2001 - 2003 Postdoctoral researcher, Department of Neurobiology, School of Basic Medical Sciences, Peking University

1998 - 2001 Ph.D., Department of Physiology, School of Medicine, Xi'an Jiao Tong University

 

Research interests

Dr. Xing’s research interests mainly focus on the mechanisms underlying chronic pain as well as pain modulation, pain memory and pain-related negative emotion. He devoted his research to elucidate the initiation, development and maintenance of chronic pain, to investigate the roles of receptors and ion channels, key molecules and signaling pathways in the pathogenesis of chronic pain, and the neurocircuitry mechanisms of chronic pain, such as the encoding of nociceptive signaling in the brain, the neural circuit of pain and its role in acupuncture-mediated analgesia. Also, he engaged his research to illuminate the mechanisms underlying the comorbidity of chronic pain with mood disorders including anxiety and depression. Moreover, Xing’s lab is also interested in the mechanisms underlying the pathogenesis of asthenozoospermia, one of the most common findings present in infertile men. Multi-disciplinary approaches and techniques are utilized in Dr. Xing’s lab, which include molecular biology, cell biology, morphology, behavioral pharmacology, iPSC, genome editing, as well as imaging, epigenetics, optogenetics, chemogenetics, and electrophysiology such as in vivo extracellular recording, patch-clamp recording, and in vivo multichannel recording in awake, freely-moving animals.

 

Awards

Second Prize, Beijing Science and Technology Award (2012)

Second Prize, Science and Technology Award, Chinese Acupuncture and Moxibustion Society (2011)

Academic and Social Activities Youth Member, Chinese Academy of Pain Committee Member,

Acupuncture Anesthesia Branch, Chinese Acupuncture and Moxibustion Society

Editors, Chinese Journal of Pain Medicine; Clinical Progress; Journal of Neuropharmacology; Journal of Pain Research; Journal of Local and Regional Anesthesia and World Journal of Anesthesiology

 

Research Funding

National Natural Science Foundation of China (81974169) “The role and the neuromodulatory circuits mechanisms for the amygdala in chronic stress-induced exacerbation of neuropathic pain” (2020 - 2023)

National Natural Science Foundation of China (81671085) “Studies on the transcriptional regulation of P2X3 purinergic receptor and its roles in cancer-induced bone pain in rats” (2017 - 2020)

National Natural Science Foundation of China (61527815) “Multi level control and high throughput neural signal detection apparatus” (2016 - 2020)

National Natural Science Foundation of China (81371237) “Studies on the transcriptional regulation of KCNQ/M(Kv7) channel and its roles in cancer-induced bone pain in rats” (2014 - 2017)

National Natural Science Foundation of China (31171063) “The role and mechanisms of KCNQ/M potassium channels in the development of bone cancer pain” (2012 -2015)

973 Program (2013CB531905) “Analgesic mechanism of acupuncture-drug compound anesthesia” (2013 - 2017)

Special Fund of Industry Special Fund of Ministry of Health (201302013-01) “Application of transcutaneous electrical stimulation technology in reproductive medicine” (2013 - 2015)

National Natural Science Foundation of China (81072951) “Roles of Sheng-Jing-San in the treatment of asthenozoospermia via the activation of CatSper channels” (2011.0 – 2011.12)

National Natural Science Foundation of China (61027001) “Development of the high throughput neural signal detection apparatus” (2011 - 2013)

Beijing Natural Science Foundation (7112079) “Roles of BDNF-mediated phosphorylation of NMDA receptor NR2B subunit in the development of neuropathic pain” (2011 – 2013)

973 Program (2007CB512501) “Role of Brain Pain Processing Circuit in Acupuncuture Analgesia” (2007 - 2011)

National Natural Science Foundation of China (30370470) “Long-term Synaptic Plasticity in the Spinal Dorsal Horn and its Modulation by Electroacupuncture in Rats with Neuropathic Pain” (2004 – 2006)

 

Selected publications (*: corresponding author)

Guihua Xiao, Yilin Song, Yu Zhang, Yu Xing, Hongyan Zhao, Jingyu Xie, Shengwei Xu, Fei Gao, Mixia Wang, Guogang Xing, Xinxia Cai. Microelectrode Arrays Modified with Nanocomposites for Monitoring Dopamine and Spike Firings under Deep Brain Stimulation in Rat Models of Parkinson's Disease. ACS Sensors.2019 Aug 23;4(8):1992-2000. doi: 10.1021/acssensors.9b00182.

Ya-Jing Liang, Shi-Yang Feng, Ya-Ping Qi, Kai Li, Zi-Run Jin, Hong-Bo Jing, Ling-Yu Liu, Jie Cai2, Guo-Gang Xing*, Kai-Yuan Fu*. Contribution of microglial reaction to increased nociceptive responses in high-fat-diet (HFD)-induced obesity in male mice. Brain, Behavior, and Immunity. 2019 May 17;80:777-792. doi: 10.1016/j.bbi.2019.05.026.

Ling-Yu Liu#, Rui-Ling Zhang, Lin Chen, Hong-Yan Zhao, Jie Cai, Jia-Kang Wang, Da-Qing Guo, Yan-Jun Cui*, Guo-Gang Xing*. Chronic stress increases pain sensitivity via activation of the rACCBLA pathway in rats. Experimental Neurology. 2018 Dec 23. pii: S0014-4886(18)30609-5. doi: 10.1016/j.expneurol. 2018.12.009.

Yue Yang#, Song Li#, Zi-Run Jin#, Hong-Bo Jing#, Hong-Yan Zhao, Bo-Heng Liu, Ya-Jing Liang, Ling-Yu Liu, Jie Cai, You Wan, Guo-Gang Xing*. Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis. Science Signaling. 2018 Oct; DOI: 10.1126/scisignal.aao5150. (Full text)

Hong-Yan Zhao, Ling-Yu Liu, Jie Cai, Yan-Jun Cui*, Guo-Gang Xing*. Electro-acupuncture Treatment Alleviates the Remifentanil-induced Hyperalgesia by Regulating the Activities of Ventral Posterior Lateral Nucleus of the Thalamus Neurons in Rats. Neural Plasticity. 2018 in press.

Lin Chen#, Song Li#, Jie Cai, Tian-Jiao Wei, Ling-Yu Liu, Hong-Yan Zhao, Bo-Heng Liu, Hong-Bo Jing, Zi-Run Jin, Min Liu, You Wan, Guo-Gang Xing*. Activation of CRF/CRFR1 signaling in the basolateral nucleus of the amygdala contributes to chronic forced swim-induced depressive-like behaviors in rats. Behavioural Brain Research. 2018; 338:134-142.

Xu Ding#, Ya-Jing Liang, Li Su, Fei-Fei Liao, Dong Fang, Jun Tai, Guo-Gang Xing*. BDNF contributes to the neonatal incision-induced facilitation of spinal long-term potentiation and the exacerbation of incisional pain in adult rats.Neuropharmacology. 2018; 137:114-132.

Ming-Jia Li#, Ling-Yu Liu#, Lin Chen#, Jie Cai, You Wan, Guo-Gang Xing*. Chronic stress exacerbates neuropathic pain via the integration of stress-affect related information and nociceptive information in the central nucleus of the amygdala. Pain. 2017 Apr;158(4):717-739.

Song Li#, Jie Cai, Zhi-Bo Feng, Zi-Run Jin, Bo-Heng Liu, Hong-Yan Zhao, Hong-Bo Jing, Tian-Jiao Wei, Guan-Nan Yang, Ling-Yu Liu, Yan-Jun Cui*, Guo-Gang Xing*. BDNF contributes to spinal long-term potentiation and mechanical hypersensitivity via Fyn-mediated phosphorylation of NMDA receptor GluN2B subunit at tyrosine 1472 in rats following spinal nerve ligation. Neurochemical Research. 2017; 42(10): 2712-2729.

Dong Fang#, Ling-Yu Kong#, Jie Cai#, Song Li, Hong-Yan Zhao, Xiao-Dan Liu, Ji-Sheng Han, Guo-Gang Xing*. Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model.Pain. 2015 Apr;156(6):1124-1144.

Jie Cai#, Dong Fang, Xiao-Dan Liu, Song Li, Juan Ren* and Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain. Oncology Reports. 2015 Mar; 33(3): 1540-1550.

Xu Ding#, Jie Cai, Song Li, Xiao-Dan Liu, You Wan, Guo-Gang Xing*. BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation. Neurobiology of Disease. 2015 Jan; 73:428-451.

Xiao-Dan Liu#, Jing-Jing Yang#, Dong Fang, Jie Cai, You Wan*, Guo-Gang Xing*. Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain. PLoS One. December 11, 2014, 9(12): e114623.

Hong Jiang#, Dong Fang#, Ling-Yu Kong, Zi-Run Jin, Jie Cai, Xue-Jing Kang, You Wan* and Guo-Gang Xing*. Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats. Molecular Brain. 2014 Oct 4; 7(1):72-93.

Lei Ding#, Jie Cai#, Xiang-Yang Guo, Xiu-Li Meng*, Guo-Gang Xing*. The anti-allodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability via decreasing the dorsal horn N-methyl-D-aspartate receptors in rats with spared nerve injury. Pain Research & Management. 2014; 19(4): 205-211.

Min Liu#, Huan Yang, Dong Fang, Jing-Jing Yang, Jie Cai, You Wan, De-Hua Chui, Ji-Sheng Han, Guo-Gang Xing*. Up-regulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglion contributes to the bone cancer pain. Pain. 2013; 154(9):1551-1568.

Qin Zheng#, Dong Fang, Ming Liu, Jie Cai, You Wan, Ji-Sheng Han,Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain. 2013; 154(3): 434-448.

Ya-Nan Wang#, Bo Wang#, Min Liang#, Cai-Yan Han, Bin Zhang, Jie Cai, Wei Sun*, Guo-Gang Xing*. Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, while up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats. Fertility and Sterility. 2013; 99(2):579-587.

Qin Zheng#, Dong Fang, Jie Cai, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain. Molecular Pain. 2012; 8(1):24-41.

Ying-Ying Wang#, Jiong Qin*, Ying Han, Jie Cai, Guo-Gang Xing*. Hyperthermia induces epileptiform discharges in cultured rat cortical neurons. Brain Research. 2011; 1417C: 87-102.

Shan-Jing Geng#, Fei-Fei Liao#, Wen-Hao Dang, Xu Ding, Xiao-Dan Liu, Jie Cai, Ji-Sheng Han, You Wan, Guo-Gang Xing*. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Experimental Neurology. 2010; 222(2):256-266.

Feng-Yu Liu#, Xiao-Xiu Qu#, Xu Ding#, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain Research. 2010; 1330:45-60.

Xiao-Xiu Qu#, Jie Cai#, Ming-Jia Li, Ye-Nan Chi, Fei-Fei Liao, Feng-Yu Liu, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. Experimental Neurology. 2009; 215(2):298-307.

Lu Yu#, Fei Yang, Hao Luo, Feng-Yu Liu, Ji-Sheng Han, Guo-Gang Xing* and You Wan*. The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant. Molecular Pain. 2008; 4(1): 61-70.

Guo-Gang Xing#,*, Feng-Yu Liu, Xiao-Xiu Qu, Ji-Sheng Han, You Wan. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Experimental Neurology. 2007; 208(2):323-332.

Feng-Yu Liu#, Guo-Gang Xing#, Xiao-Xiu Qu, Isabella S. Xu, Ji-Sheng Han, You Wan*. Roles of 5-HT receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. The Journal of Pharmacology and Experimental Therapeutics. 2007; 321(3): 1046-1053.

Guo-Gang Xing#,Rengang Wang#, Bo Yang, Dongxian Zhang*. Postnatal switching of NMDA receptor subunits from NR2B to NR2A in rat facial motor neurons. European Journal of Neuroscience. 2006; 24(11):2987-2992.

Qian Sun#, Guogang Xing#, Huiyin Tu, Ji-Sheng Han, You Wan*. Inhibition of hyperpolarization- activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain. Brain Research. 2005; 1032(1-2): 63-9.