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王晓明

 

 

王晓民,医学博士,

北京大学兼职教授, 博士生导师。

首都医科大学教授

首都医科大学副校长

现兼任中国神经科学学会副理事长,中国生理学会秘书长及神经科学专业委员会主任委员,北京神经科学学会理事长等职;兼任《中华神经医学杂志》、《基础医学与临床》副主编等数种杂志编委会常务编委或委员。

联系方式:

地址:北京市海淀区学院路38号 100083,北京大学神经科学研究所

电话:(010)-82802411(010)-83911007

Email:xmwang@bjmu.edu.cn; xmwang@cpums.edu.cn

 

研究方向目前在国家重大基础研究项目(973)-“脑功能与脑重大疾病的基础研究”;国家高技术研究计划(863)-“神经系统疾病的基因治疗研究”;北京市自然科学基金委重点项目-“神经系统胚胎干细胞及成体干细胞研究与应用”以及国家自然科学基金委、教育部等多项基金的资助下,应用多学科的先进技术,从整体-细胞-分子多层次,多角度的进行帕金森病和阿尔茨海默病的发病机制和防治基础研究。正在进行的课题包括:

l帕金森病发病机制的研究;

l可调控的启动子介导TH-GDNF双基因治疗帕金森病动物的作用研究;

l针刺治疗帕金森病动物的作用及机理研究;

l天然药物单体防治帕金森病动物的作用及机制研究;

l神经系统胚胎干细胞的定向诱导分化及成体干细胞的原位激活在防治帕金森病动物中的作用及机理研究;

l阿尔茨海默病发病机制的研究;

l天然药物单体防治阿尔茨海默病动物的作用及机制研究。

代表性论著:

1. Xi-Bin Liang, Xian-Yu Liu, Feng-Qiao Li, Yong Luo, Jun Lu,Wang-Ming Zhang, Xiao-Min Wang*, Ji-Sheng Han. Long-term high frequency electro-acupuncture stimulation prevents neuronal degeneration and upregulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy. Molecular Brain Research, 20021085159

2. Feng-Qiao Li, Xiao-Xin Cheng, Xi-Bin Liang, Xin-Hong Wang,Bing Xue, Qi-Hua He,*Xiao-Min Wang*, Ji-Sheng Han. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium Wilfordii Hook F, on dopaminergic neurons. Experimental Neurology ,20031792837

3. M Fang, Y Wang, QH He, YQ Sun, LB Deng, XW Wang and JS Han. Glial cell line-derived Neurotrophic Factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model. Neuroscience, 2003, 117: 503-512

4. Hui-Fang Zhou, Bing Xue, Feng-Qiao Li, Xian-Yu Liu, Qi-Hua He, Xin-Hong Wang and Xiao-Min Wang*. Triptolide (PG490) inhibits TNF-α, IL-1β and NO production in primary microglia-enriched cultures. NeuroReport, 2003 14:1091-1095

5. Xi-Bin Liang, Yong Luo, Xian-Yu Liu, Jun Lu, Feng-Qiao Li, Qian Wang, Xiao-Min Wang*, Ji-Sheng Han. Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats. NeuroReport, 2003 ;14(8):1177-81

6. Feng-Qiao Li, Xiu-Zhi Lu, Xi-Bin Liang, Hui-Fang Zhou, Bing Xue, Xian-Yu Liu, Dong-Bin Niu, Ji-Sheng Han, Xiao-Min Wang*. Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation. J Neuroimmunology, 2004,148: 24-31

7. Xuan Wang, Xiaoxia Li, Kun Wang, Huifang Zhou, Bing Xue, Linsong Li, Xiaomin Wang*.Forskolin Cooperating with Growth Factor on Generation of Dopaminergic Neurons from Human Fetal Mesencephalic Neural Progenitor Cells. Neuroscience Letters, 2004, 362117-121

8. Kun Wang, Jian-Jun Wang, Yue Wang, Qi-Hua He, Xuan Wang and Xiao-Min Wang*.Intrastriatal Administration of Epidermal Growth Factor and Fibroblast Growth Factor-2 Up-Regulate Proliferation and Neuronal Differentiation of Adult Neural Progenitor Cells Derived From the Striatum In Parkinsonian Rats.Neuroscience Letters, 2004, 364(3):154-158

9. Xuan Wang, Yanyan Lu, Huanqing Zhang, Kun Wang, Qihua He, Yue Wang, Xianyu Liu, Linsong Li, Xiaomin Wang*. Distinct Efficacy of Pre-differentiated Versus Intact Fetal Mesencephalon-Derived Human Neural Progenitor Cells in Alleviating Rat Model of Parkinson’s Disease.International Journal of Developmental Neuroscience, 2004, 22 (4): 175-183

10. Xian-Yu Liu, Hui-Fang Zhou, Yan-Li Pan, Xi-Bin Liang, Dong-Bin Niu, Bing Xue, Feng-Qiao Li, Qi-Hua He, Xin-Hong Wang, and Xiao-Min Wang*. Electro-acupuncture stimulation protects dopaminergic neurons from inflammation-mediated damage in medial forebrain bundle transected rats. Experimental Neurology, 2004, 189189– 196