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刘风雨副教授简介

  

             刘风雨博士,副教授

     联系方式:北京市海淀区学院路38号北京大学医学部神经科学研究所

     邮编:100191

     电话:82801067

     E-mail: liufyu@bjmu.edu.cn

   主要学习及工作经历:  

   1994. 9 — 1999. 6 山东医科大学1999. 7 — 2002. 6 山东大学基础医学院生理学系硕士

   2002. 9 — 2005. 6 北京大学基础医学院神经生物学系博士

   2005. 8 — 2013.7  北京大学基础医学院神经生物学系讲师

   2010. 9 — 2011.11 香港大学李嘉诚医学院生理学系访问学者

   2013. 7 — 北京大学基础医学院神经生物学系副教授

   中华医学会疼痛学分会第六届委员会青委会委员;《中国疼痛医学杂志》编委

   研究方向: 

   疼痛与镇痛的神经生物学机制、尤其是慢性痛的机制。采用电生理学(包括在体电生理和膜片钳实验技术)、分子生物学、形态学、细胞生物学和行为药理学等方法,研究背根神经节、脊髓背角等部位神经元和胶质细胞、神经递质及受体、离子通道在慢性痛中的作用。目的在于阐明慢性痛的发病机制,并寻找新的疼痛干预靶点。

   基金来源:  

2015-2019:国家重点基础研究发展计划“973计划”(2015CB554503

2014:国家自然科学基金委面上项目(31371119

2009-2011:教育部科学技术研究重点项目(109003

2007-2009:国家自然科学基金委面上项目(青年科学基金项目)(30600173

2006-2008:北京大学基础医学院“985”青年人才科研启动基金

   获奖情况:

2014年度“北京大学第十四届青年教师教学基本功比赛(医科类)”二等奖

2014年度“北京大学基础医学院第十四届青年教师教学演示竞赛”二等奖

2014年度“北京大学基础医学院优秀教师奖”

2012年度“北京市科学技术奖”二等奖(第五完成人)

2010年度“中国针灸学会科学技术奖”二等奖(第四完成人)

2010年度“北京大学医学部级优秀教师奖”

2010年度“北京大学基础医学院第九届青年教师教学演示竞赛”三等奖

2008年度“北京大学医学部青年岗位能手”称号

   代表论文:(CA标示通讯作者*标示共同第一作者)  

Jia Liu*, Feng-Yu Liu*, Zhi-Qian Tong, Zhi-Hua Li, Wen Chen, Wen-Hong Luo, Hui Li, Hong-Jun Luo, Yan Tang, Jun-Min Tang, Jie Cai, Fei-Fei Liao, You WanCA. Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats. Plos One 2013; 8(3):e58957.

Feng-Yu Liu, Xiao-Xiao Qu, Jie Cai, Fa-Tian Wang, Guo-Gang Xing,You Wan CA. Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation. Neuroscience Bulletin 2011; 27(1):1-8.

Feng-Yu Liu*, Xiao-Xiu Qu*, Xu Ding*, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xing CA. Decrease in the descending inhibitory5-HT system in rats with spinal nerve ligation. Brain Research 2010; 1330: 45-60.

Feng-Yu Liu*, Guo-Gang Xing*, Xiao-Xiu Qu, Isabella Shi Xu, Ji-Sheng Han, You Wan CA. Roles of 5-HT receptor subtypes in the inhibitory effects of 5-HT on the C-fiber responses of the spinal wide dynamic range neurons in rats. Journal of Pharmacology and Experimental Therapeutics 2007; 321(3): 1046-1053.

Feng-Yu Liu, Chuan-Yong Liu CA, Jing-Zhang Liu, Dong-Ping Xie. The Caudal Ventrolateral Medulla participates in the regulation of gallbladder motility in rabbits. Chinese Journal of Physiology 2004; 47(1): 1-6.

Xing Xiao, Xiao-Tao Zhao, Ling-Chi Xu, Lu-Peng Yue, Feng-Yu Liu, Jie Cai, Fei-Fei Liao, Jin-Ge Kong, Guo-Gang Xing, Ming Yi, You WanCA. Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats. Pain 2015; 156(4):597-608.

Yu Zhang, Feng-Yu Liu, Fei-Fei Liao, You Wan, Ming YiCA. Exacerbation of tonic but not phasic pain by entorhinal cortex lesions. Neuroscience Letters 2014; 81:137-142.

Fei Yang, Jia Guo, Wei-Liang Sun, Feng-Yu Liu, Jie Cai, Guo-Gang Xing, You WanCA. The Induction of long-term potentiation in spinal dorsal horn after peripheral nociceptive stimulation and contribution of spinal TRPV1 in rats. Neuroscience 2014; 269: 59-66.

Yan Li, Jie Cai, Ying Han, Xing Xiao, Xiang-Ling Meng, Li Su, Feng-Yu Liu, Guo-Gang Xing, You WanCA. Enhanced function of TRPV1 via up-regulation by insulin-like growth factor-1 in a rat model of bone cancer pain. European Journal of Pain 2014; 18(6):774-784.

Ye-Nan Chi, Xu Zhang, Jie Cai, Feng-Yu Liu, Guo-Gang Xing, You WanCA. Formaldehyde increases intracellular calcium concentration in primary cultured hippocampal neurons partially through NMDA receptors and T-type calcium channels. Neuroscience Bulletin 2012; 28(6):715-722.

Ying Han*, Yan Li*, Xing Xiao, Jia Liu, Guo-Gang Xing, Xiang-Ling Meng, Feng-Yu Liu, Guo-Gang Xing, You Wan CA. Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in bone cancer pain model of rats. Neuroscience Bulletin 2012; 28(2):165-172.

Feng-Yu Liu*, Yan-Ni Sun*, Fa-Tian Wang*, Qian Li, Li Su, Zi-Fang Zhao, Xiang-Ling, Hong Zhao, Xi Wu, Qian Sun, Guo-Gang XingCA, You WanCA. Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation. Brain Research 2012; 1427:65-77.

Jing Wang, Duan Li, Xiao-Li Li, Feng-Yu Liu, Guo-Gang Xing, Jie Cai, You Wan CA. Phase – amplitude coupling between theta and gamma oscillations during nociception in rat electroencephalogram.Neuroscience Letters 2011; 499: 84-87.

Zhi-Qian Tong*CA , Wen-Hong Luo*, Yan-Qing Wang*, Fei Yang, Ying Han, Hui Li, Hong-Jun Luo, Bo Duan, Tian-Le Xu, Qiliang Mao-Ying, Huang-Ying Tan, Jun Wang, Hong-Mei Zhao, Feng-Yu Liu, You Wan CA. Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. Plos One 2010; 5(4): e10234.

Xiao-Xiu Qu, Jie Cai, Ming-Jia Li, Ye-Nan Chi, Fei-Fei Liao, Feng-Yu Liu, You Wan, Ji-Sheng Han, Guo-Gang Xing CA. Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. Experimental Neurology 2009; 215(2): 298-307.

Lu Yu, Fei Yang, Hao Luo, Feng-Yu Liu, Ji-Sheng Han, Guo-Gang Xing, You Wan CA. The role of TRPV1 in different types of dorsal root ganglion neurons in chronic inflammatory nociception induced by complete Freund’s adjuvant. Molecular Pain 2008; 4: 61 (10 pages).

Hao Luo, Isabella Shi Xu, Yi Chen, Lu Yu, Fei Yang, Guang-Xin Li, Feng-Yu Liu, Guo-Gang Xing, Yu-Shun Shi, Tan Li, Ji-Sheng Han, You Wan CA. Behavioral and electrophysiological evidence for the differential functions of TRPV1 at early and late stages of chronic inflammatory nociception in rats. Neurochemical Research 2008; 33(10): 2151-2158.

Yu-Qiu Jiang, Guo-Gang Xing, Sheng-Lan Wang, Hui-Yin Tu, Ye-Nan Chi, Jie Li, Feng-Yu Liu, Ji-Sheng Han, You Wan CA. Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat. Pain 2008; 137: 495-506.

Yue Lu, Yan-Ni Sun, Xi Wu, Qian Sun, Feng-Yu Liu, Guo-Gang Xing, You Wan CA. Role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat. Brain Research 2008; 1200: 19-26.

Guo-Gang Xing CA, Feng-Yu Liu, Xiao-Xiu Qu, Ji-Sheng Han, You Wan CA. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Experimental Neurology 2007; 208(2):323-332.

   论著:

   万有,刘风雨。第36章:神经病理性痛基本原理。第473-480页。见:韩济生主编,樊碧发副主编。疼痛学(第一版)。北京大学医学出版社20122月,北京。