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邢国刚教授课题组

  

  

 邢国刚,医学博士,博士后学历,北京大学教授,博士生导师;

 

中国神经科学学会神经内稳态与内分泌分会常务委员、中国神经科学学会感觉运动分会委员、中华医学会疼痛学分会委员、中国针灸学会针刺麻醉分会委员。中国疼痛医学杂志, 神经药理学报, 临床医学进展, Journal of Pain Research, Journal of Local and Regional Anesthesia, The World Journal of Anesthesiology等学术期刊编委

  

联系方式:

 

地址:北京市海淀区学院路38号北京大学神经科学研究所

邮编:北京100083

电话:(010)-82805842

E-mail: ggxing@bjmu.edu.cn

  

主要经历:

 

2001年于西安交通大学获得博士学位,同年进入北京大学神经科学研究所博士后流动站,从事慢性痛的发病机制研究。2004-2006年先后在美国Sanford-Burnham医学研究所和威斯康星大学生理系做高级访学。回国后任北京大学神经生物学系副教授、教授。主持和承担包括国家自然科学基金、北京市自然科学基金、国家重点基础研究发展计划(973”计划)课题、国家重大科研仪器研制项目、国家卫生健康委员会行业专项基金等多项国家级与省部级课题,发表研究论文90余篇,其中SCI收录论文46篇。参加编写教材8部。获得2012年北京市科学技术奖二等奖(第3完成人)和2010年中国针灸学会科学技术奖二等奖(第3完成人)2项。

 

 

研究方向:

 

1.  离子通道与慢性痛的记忆、认知和情绪机制研究

    采用分子生物学、细胞生物学、形态学和行为药理学的方法,结合电生理学、光遗传学和表观遗传学技术,从分子、细胞水平,突触水平,以及神经网络水平来研究离子通道与慢性痛的记忆、认知和负性情绪机制,包括恐惧记忆、认知障碍、焦虑和抑郁。

2.  痛与痛觉调制的高级神经网络机制

    运用光遗传学技术结合多通道神经元放电同步记录技术,及多通道脑电与诱发电位同步记录技术,研究痛觉信息在高级脑区的传递通路、组成的神经网络以及痛觉信息在高级脑区的编码过程。

3.  少弱精子症的发病机制与防治措施研究

    采用分子生物学、细胞生物学、形态学和行为药理学的方法,结合电生理学和表观遗传学技术,研究精子表达的特异性离子通道在少弱精子症发生的作用及机制。

      

    

科研基金: 

 

 

2017.01-2020.12: 国家自然科学基金面上项目“P2X3嘌呤能受体的转录调控及其在大鼠骨癌痛中的作用研究”(81671085)

2016.01-2020.12: 国家重大科研仪器研制项目多层次调控与高通量神经信号同步检测仪器”(61527815)

2014.01-2017.12: 国家自然科学基金面上项目“KCNQ/M(Kv7)钾通道的转录抑制调控及其在大鼠骨癌痛中的作用研究”(81371237)

2013.01-2017.12: 国家重点基础研究发展计划(973计划)课题针药复合麻醉镇痛机制研究”(2013CB531905)

2013.01-2017.12: 国家卫生和计划生育委员会行业专项基金经皮穴位电刺激技术在生殖医学中的应用研究”(201302013-01)

2012.01-2015.12: 国家自然科学基金面上项目“KCNQ/M电压门控钾通道在骨癌痛中的作用及机制研究”(31171063)

2011.01-2011.12: 国家自然科学基金预探索项目生精散激活精子特异性钙通道蛋白CatSper治疗弱精子症的临床与基础研究”(81072951)

2011.01-2013.12: 国家自然科学基金(仪器专项)“高通量神经信息检测分析仪器研制”(61027001)

2011.01-2013.12: 北京市自然科学基金面上项目“BDNF激活NMDA受体2B亚基磷酸化在神经病理痛中的作用”(7112079)

2008.06-2011.06: 教育部留学回国人员基金背根神经节神经元超极化激活电流(Ih)参与大鼠神经病理痛的分子机制”(2008890)

2007.07-2011.08: 国家重点基础研究发展计划(973计划)课题针麻镇痛中高级中枢痛觉信息调制回路的作用”(2007CB512501)

2004.01-2006.12: 国家自然科学基金面上项目脊髓背角突触传递的长时程抑制在电针治疗神经病理痛中的作用及其机理研究”(30370470)

 

 

获奖情况:

 

  1. (1)2015年北京大学基础医学院SCI论文引用奖
  2. (2)2014韩济生疼痛医学论文奖(三等奖)
  3. (3)2012年度北京市科学技术奖(二等奖) (针刺治疗慢性痛的神经生物学机制研究) (证书号: 2012-2-002-03,完成人:韩济生、万有、邢国刚等)
  4. (4)2012年基础医学院优秀SCI论文(二等奖)
  5. (5)2012年北京大学基础医学院SCI论文引用奖(2)
  6. (6)2011年北京大学基础医学院SCI论文引用奖
  7. (7)2010年中国针灸学会科学技术奖(二等奖) (中医针灸学理论指导下针刺镇痛的神经生物学机制研究) (证书号: ZJ2010003-2-03,完成人:万有、黄诚、邢国刚等)
  8. (8)2009年度北京大学医学部优秀教师奖

 

发表的SCI论文(*通讯作者; #共同第一作者):

 

  1. 1. Yue Yang#, Song Li#, Zi-Run Jin#, Hong-Bo Jing#, Hong-Yan Zhao, Bo-Heng Liu, Ya-Jing Liang, Ling-Yu Liu, Jie Cai, You Wan, Guo-Gang Xing*. Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis. Science Signaling. 2018 Oct; DOI: 10.1126/scisignal.aao5150. (Full text)
  2.  
  3. 2. Hong-Yan Zhao, Ling-Yu Liu, Jie Cai, Yan-Jun Cui*, Guo-Gang Xing*. Electro-acupuncture Treatment Alleviates the Remifentanil-induced Hyperalgesia by Regulating the Activities of Ventral Posterior Lateral Nucleus of the Thalamus Neurons in Rats. Neural Plasticity. 2018 in press.
  4.  
  5. 3. Lin Chen#, Song Li#, Jie Cai, Tian-Jiao Wei, Ling-Yu Liu, Hong-Yan Zhao, Bo-Heng Liu, Hong-Bo Jing, Zi-Run Jin, Min Liu, You Wan, Guo-Gang Xing*. Activation of CRF/CRFR1 signaling in the basolateral nucleus of the amygdala contributes to chronic forced swim-induced depressive-like behaviors in rats. Behavioural Brain Research. 2018; 338:134-142.
  6.  
  7. 4. Xu Ding#, Ya-Jing Liang, Li Su, Fei-Fei Liao, Dong Fang, Jun Tai, Guo-Gang Xing*. BDNF contributes to the neonatal incision-induced facilitation of spinal long-term potentiation and the exacerbation of incisional pain in adult rats.Neuropharmacology. 2018; 137:114-132.
  8.  
  9. 5. Ming-Jia Li#, Ling-Yu Liu#, Lin Chen#, Jie Cai, You Wan, Guo-Gang Xing*. Chronic stress exacerbates neuropathic pain via the integration of stress-affect related information and nociceptive information in the central nucleus of the amygdala. Pain. 2017 Apr;158(4):717-739.
  10.  
  11. 6. Song Li#, Jie Cai, Zhi-Bo Feng, Zi-Run Jin, Bo-Heng Liu, Hong-Yan Zhao, Hong-Bo Jing, Tian-Jiao Wei, Guan-Nan Yang, Ling-Yu Liu, Yan-Jun Cui*, Guo-Gang Xing*. BDNF contributes to spinal long-term potentiation and mechanical hypersensitivity via Fyn-mediated phosphorylation of NMDA receptor GluN2B subunit at tyrosine 1472 in rats following spinal nerve ligation. Neurochemical Research. 2017; 42(10): 2712-2729.
  12.  
  13. 7. Fan Qu#, Rong Li, Wei Sun, Ge Lin, Rong Zhang, Jing Yang, Li Tian, Guo-Gang Xing, Hui Jiang, Fei Gong, Xiao-Yan Liang, Yan Meng, Jia-Yin Liu, Li-Ying Zhou, Shu-Yu Wang, Yan Wu, Yi-Jing He, Jia-Yu Ye, Song-Ping Han, Ji-Sheng Han*. Use of electroacupuncture and transcutaneous electrical acupoint stimulation in reproductive medicine: a group consensus. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology). 2017 18(3):186-193.
  14.  
  15. 8. Li Li#, Qinghai Liu, Long Fan, Wei Xiao, Lei Zhao, Yu Wang, Weiguang Ye, Fei Lan, Bin Jia, Hua Feng, Changman Zhou, Xiuqin Yue, Guo-Gang Xing*, Tianlong Wang*. Protective effects of oxymatrine against arsenic trioxide-induced liver injury. Oncotarget.2017 Feb 21;8(8):12792-12799.
  16.  
  17. 9.Yi-Jing Li#, Xing-Jie Ping, Chong Qi, Fang Shen, Lin-Lin Sun, Xiao-Wei Sun, Fei-Fei Ge, Guo-Gang Xing and Cai-Lian Cui*. Re-exposure to morphine-associated context facilitated long-term potentiation in the vSUB-NAc glutamatergic pathway via GluN2B-containing receptor activation. Addiction Biology. 2017 Mar; 22(2):435-445. doi: 10.1111/adb.12343. Epub 2015 Dec 22.
  18.  
  19. 10. Jing Wang#, Jing Wang, Guo-Gang Xing, Xiao-Li Li* and You Wan*. Enhanced Gamma Oscillatory Activity in Rats with Chronic Inflammatory Pain. Frontiers in Neuroscience, 2016 Nov 1;10:489. eCollection 2016.
  20.  
  21. 11. Dong Fang#, Ling-Yu Kong#, Jie Cai#, Song Li, Hong-Yan Zhao, Xiao-Dan Liu, Ji-Sheng Han, Guo-Gang Xing*. Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model. Pain. 2015 Apr;156(6):1124-1144.
  22.  
  23. 12.Xing Xiao#, Xiao-Tao Zhao, Ling-Chi Xu, Lu-Peng Yue, Feng-Yu Liu, Jie Cai, Fei-Fei Liao, Jin-Ge Kong, Guo-Gang Xing, Ming Yi, You Wan*. Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats.Pain. 2015 Apr;156(4):597-608.
  24.  
  25. 13.Jie Cai#, Dong Fang, Xiao-Dan Liu, Song Li, Juan Ren* and Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain. Oncology Reports. 2015 Mar; 33(3): 1540-1550.
  26.  
  27. 14.Xu Ding#, Jie Cai, Song Li, Xiao-Dan Liu, You Wan, Guo-Gang Xing*. BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation. Neurobiology of Disease. 2015 Jan; 73:428-451.
  28.  
  29. 15.Xiao-Dan Liu#, Jing-Jing Yang#, Dong Fang, Jie Cai, You Wan*, Guo-Gang Xing*. Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain. PLoS One. December 11, 2014, 9(12): e114623.
  30.  
  31. 16.Hong Jiang#, Dong Fang#, Ling-Yu Kong, Zi-Run Jin, Jie Cai, Xue-Jing Kang, You Wan* and Guo-Gang Xing*. Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats. Molecular Brain. 2014 Oct 4; 7(1):72-93.
  32.  
  33. 17.Lei Ding#, Jie Cai#, Xiang-Yang Guo, Xiu-Li Meng*, Guo-Gang Xing*. The anti-allodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability via decreasing the dorsal horn N-methyl-D-aspartate receptors in rats with spared nerve injury. Pain Research & Management. 2014; 19(4): 205-211.
  34.  
  35. 18.Yan Li,#Jie Cai, Yin Han, Xin Xiao, Xiang-Lin Meng, Li Su, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Enhanced function of TRPV1 via up-regulation by insulin-like growth factor-1 in a rat model of bone cancer pain. European Journal of Pain.2014; 18(6):774-84.
  36.  
  37. 19.Fei Yang#, Jia Guo, Wei-Liang Sun, Feng-Yu Liu, Jie Cai, Guo-Gang Xing, You Wan*.The Induction of Long-Term Potentiation in Spinal Dorsal Horn after Peripheral Nociceptive Stimulation and Contribution of Spinal TRPV1 in Rats.Neuroscience. 2014; 269: 59-66.
  38.  
  39. 20.Ling Hu#, Xiang-Hong Jing, Cai-Lian Cui, Guo-Gang Xing, Bing Zhu*. NMDA receptors in the midbrain play a critical role in dopamine-mediated hippocampal synaptic potentiation caused by morphine. Addiction Biology. 2014; 19(3):380-91.
  40.  
  41. 21.Liu X#, Zhang B, Yang H, Wang H, Liu Y, Huang A, Liu T, Tian X, Tong Y, Zhou T, Zhang T, Xing GG, Xiao W, Guo X*, Fan D*, Han X, Liu G*, Zhou Z*, Chui D*. Impaired synaptic vesicle recycling contributes to presynaptic dysfunction in lipoprotein lipase-deficient mice.Neuroscience. 2014 Nov 7; 280:275-281.
  42.  
  43. 22.Min Liu#, Huan Yang, Dong Fang, Jing-Jing Yang, Jie Cai, You Wan, De-Hua Chui, Ji-Sheng Han, Guo-Gang Xing*. Up-regulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglion contributes to the bone cancer pain. Pain. 2013; 154(9):1551-1568.
  44.  
  45. 23.Qin Zheng#, Dong Fang, Ming Liu, Jie Cai, You Wan, Ji-Sheng Han,Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain. 2013; 154(3): 434-448.
  46.  
  47. 24.Ya-Nan Wang#, Bo Wang#, Min Liang#, Cai-Yan Han, Bin Zhang, Jie Cai, Wei Sun*, Guo-Gang Xing*. Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, while up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats. Fertility and Sterility. 2013; 99(2):579-587.
  48.  
  49. 25.Qin Zheng#, Dong Fang, Jie Cai, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain. Molecular Pain. 2012; 8(1):24-41.
  50.  
  51. 26.Feng-Yu Liu#, Yan-Ni Sun#, Fa-Tian Wang#, Qian Li, Li Su, Zi-Fang Zhao, Xiang-Ling Meng, Hong Zhao, Xi Wu, Qian Sun, Guo-Gang Xing*, You Wan*. Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation. Brain Research. 2012; 1427:65-77.
  52.  
  53. 27.Yilin Song#, Nansen Lin, Chunxiu Liu, Hong Jiang, Guogang Xing, Xinxia Cai*. A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro.Biosensors and Bioelectronics. 2012; 38(1):416-20.
  54.  
  55. 28.Ye-Nan Chi#, Xu Zhang, Jie Cai, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Formaldehyde increases intracellular calcium concentration in primary cultured hippocampal neurons through NMDA receptors and T-type calcium channels. Neuroscience Bulletin. 2012; 28(6):715-22.
  56.  
  57. 29.Ying Han#, Yan Li, Xing Xiao, Jia Liu, Xiang-Ling Meng, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone cancer pain. Neuroscience Bulletin. 2012; 28(2):165-72.
  58.  
  59. 30.Ying-Ying Wang#, Jiong Qin*, Ying Han, Jie Cai, Guo-Gang Xing*. Hyperthermia induces epileptiform discharges in cultured rat cortical neurons. Brain Research. 2011; 1417C: 87-102.
  60.  
  61. 31.Ming Yi#, Haolin Zhang#, Lixing Lao, Guo-Gang Xing, You Wan*. Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats. Molecular Pain. 2011; 7(1):61.
  62.  
  63. 32.Jing Wang#, Duan Li, Xiaoli Li, Feng-Yu Liu, Guo-Gang Xing, Jie Cai and You Wan*. Phase–amplitude coupling between theta and gamma oscillations during nociception in rat electroencephalography. Neuroscience Letters. 2011; 499(2):84-87.
  64.  
  65. 33.Feng-Yu Liu#, Xiao-Xiu Qu, Jie Cai, Fa-Tian Wang, Guo-Gang Xing, You Wan*. Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation. Neuroscience Bulletin. 2011; 27(1):1-8.
  66.  
  67. 34.Shan-Jing Geng#, Fei-Fei Liao#, Wen-Hao Dang, Xu Ding, Xiao-Dan Liu, Jie Cai, Ji-Sheng Han, You Wan, Guo-Gang Xing*. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Experimental Neurology. 2010; 222(2):256-266.
  68.  
  69. 35.Feng-Yu Liu#, Xiao-Xiu Qu#, Xu Ding#, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain Research. 2010; 1330:45-60.
  70.  
  71. 36.Tianran Song, Yue Wang, Guian Chen* and Guogang Xing*. Tyrosine hydroxylase- positive cells and dopaminergic neuronal function in human embryonic stem cells: An electrophysiological validation.Neural Regeneration Research. 2010; 5(3):185-190.
  72.  
  73. 37.Xiao-Xiu Qu#, Jie Cai#, Ming-Jia Li, Ye-Nan Chi, Fei-Fei Liao, Feng-Yu Liu, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. Experimental Neurology. 2009; 215(2):298-307.
  74.  
  75. 38.Lu Yu#, Fei Yang, Hao Luo, Feng-Yu Liu, Ji-Sheng Han, Guo-Gang Xing* and You Wan*. The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant. Molecular Pain. 2008; 4(1): 61-70.
  76. 39.Yu-Qiu Jiang#, Guo-Gang Xing, Sheng-Lan Wang, Hui-Yin Tu, Ye-Nan Chi, Jie Li, Feng-Yu Liu, Ji-Sheng Han, You Wan*. Axonal accumulation of hyperpolarization- activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat. Pain. 2008; 137: 495-506.
  77.  
  78. 40.Yue Lu#, Yan-Ni Sun, Xi Wu, Qian Sun, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Role of alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat. Brain Research. 2008; 1200C:19-26.
  79.  
  80. 41.Hao Luo#, Isabella Shi Xu, Yi Chen, Fei Yang, Lu Yu, Guang-Xin Li, Feng-Yu Liu, Guo-Gang Xing, Yu-Shun Shi, Tan Li, Ji-Sheng Han and You Wan*. Behavioral and Electrophysiological Evidence for the Differential Functions of TRPV1 at Early and Late Stages of Chronic Inflammatory Nociception in Rats. Neurochemical Research. 2008; 33(10):2151-8.
  81.  
  82. 42. Guo-Gang Xing#,*, Feng-Yu Liu, Xiao-Xiu Qu, Ji-Sheng Han, You Wan. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Experimental Neurology. 2007; 208(2):323-332.
  83.  
  84. 43.Feng-Yu Liu#, Guo-Gang Xing#, Xiao-Xiu Qu, Isabella S. Xu, Ji-Sheng Han, You Wan*. Roles of 5-HT receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. The Journal of Pharmacology and Experimental Therapeutics. 2007; 321(3): 1046-1053.
  85.  
  86. 44. Guo-Gang Xing#,Rengang Wang#, Bo Yang, Dongxian Zhang*. Postnatal switching of NMDA receptor subunits from NR2B to NR2A in rat facial motor neurons. European Journal of Neuroscience. 2006; 24(11):2987-2992.
  87.  
  88. 45.Qian Sun#, Guogang Xing#, Huiyin Tu, Ji-Sheng Han, You Wan*. Inhibition of hyperpolarization- activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain. Brain Research. 2005; 1032(1-2): 63-9.
  89.  
  90. 46.Qian Sun#, Huiyin Tu#, Guogang Xing, Ji-Sheng Han, You Wan*. Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation. Experimental Neurology. 2005; 191(1): 128-36.