Dr. Hong Jiang

Principal Investigator

Neuroscience Research Institute

Peking University

38 Xueyuan Road

Beijing 100191, China

Email: hong.jiang@hsc.pku.edu.cn

Research Interest

Our laboratory focuses on investigating how metabolic status affects pain sensory as well as sleep/wakefulness homeostasis. We employ modern system neuroscience state of the art techniques including brain slice patch clamp, neurocircuit tracing, optogenetics/chemogenetics, fiberphotometry, EEG/EMG recording combing with single nucleus sequencing and riboTrap based translatome technique. Based on the pain model, metabolic disorder as well as sleep deprivation models, we aim, combing with transgenic mice and rodent behaviors methods, to study physiology as well as pathology of underlying neurocircuitry mechanisms from molecular, synapse to neurocircuit levels in rodents.

Education and Academic Achievements

2022 ~Present     Tenure-Track Assistant Professor/Principle Investigator
                            Department of Neurobiology, Neuroscience Research Institute
                            Peking University, Beijing, China

2015 ~ 2022       Postdoctoral Fellow
                           Department of Neuronal Control of Metabolism,
                           Max Planck Institute for Metabolism Research, Cologne, Germany
                           Mentor: Prof. Dr. Jens C. Brüning, Group leader and Director of the institute

2008～2014       Ph.D. in Neurobiology, Department of Neurobiology,
                           School of Basic Medical Science, Peking University, Beijing, China.
                           Mentors: Prof. You Wan, Prof. Guo-Gang Xing

2003～2008      M.D. in Clinical Medicine,
                          Zheng Zhou University, Henan, China.

Publications

1. Y. Wang, S. Fu, J. Mao, K. Cui, Hong Jiang#, Hypocretin: a promising target for the regulation of homeostasis, Frontiers in Neuroscience Volume 19 - 2025 (2025).

2. Chen, Xiangtong, Yutong Wang, Su Fu, You Wan, Jian Mao, Kun Cui, and Hong Jiang#. 2025. The Integrated Function of the Lateral Hypothalamus in Energy Homeostasis, Cells 14, no. 14: 1042

3. S. Izawa, D. Fusca, Hong Jiang, C. Heilinger, A.C. Hausen, F.T. Wunderlich, L. Steuernagel, P. Kloppenburg, J.C. Bruning, Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity, Cell Reports 44(2) (2025) 115277.

4. Hong Jiang#. Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control, Medical Review, vol. 2, no. 5, 2022, pp. 531-540.

5. Hong Jiang*, Jiang-Ping Liu, Ke Xi, Ling-Yu Liu, Ling-Yu Kong, Jie Cai, Si-Qing Cai, Xi-Yuan Han, Jing-Gui Song, Xiao-Mei Yang, You Wan, Guo-Gang Xing. Contribution of AMPA receptor-medi ated LTD in LA/BLA-CeA pathway to comorbid aversive and depressive symptoms in neuropathic pain, the Journal of Neuroscience, 2021, 41(34): 7278-7299

6.Hong Jiang*, Sarah Gallet, Paul Klemm, Pia Scholl, Kat Folz-Donahue, Janine Altmüller, Jens Alber, Christian Heilinger, Christian Kukat, Helge Müller-Fielitz, Sivaraj Sundaram, Markus Schwaninger, Vincent Prevot and Jens C. Brüning. MCH Neurons Regulate Permeability of the Median Eminence Barrier. Neuron. 2020, July 22; 107: 1-14.

7. Hong Jiang*, Jens C. Brüning. Melanin-Concentrating Hormone-Dependent Control of Feeding: When Volume Matters. Cell Metabolism. 2018, July 3; 28(1): 7-8.

8. A. Christine Hausen, Johan Ruud, Hong Jiang, Simon Hess, Hristo Varbanov, Peter Kloppenburg, Jens C. Brüning. Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity. Cell Reports. 2016, 17: 2512–2521

9. Hong Jiang*, Dong Fang, Ling-Yu Kong, Zi-Run Jin, Xue-Jing Kang, Jie Cai, You Wan, Guo-Gang Xing. Sensitization of Neurons in the Central Nucleus of the Amygdala via the Decreased GABAergic Inhibition Contributes to the Development of Neuropathic Pain-Related Anxiety-like Behaviors in Rats. Molecular Brain. 2014, 7: 72.