/HomePage/Research/ Publications

Representative Publications of the Department (2010 - 2015)

Wang GQ, Cen C, Li C, Cao S, Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LP, Wang Y. Deactivation of excitatory neurons in the contralateral prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun. 2015;6:7660.

Tong Y, Sun Y, Tian X, Zhou T, Wang H, Zhang T, Zhan R, Zhao L, Kuerban B, Li Z,Wang Q, Jin Y, Fan D, Guo X, Han H, Qin S, Chui DH. Phospholipid transfer protein (PLTP) deficiency accelerates memory dysfunction through altering amyloid precursor protein (APP) processing in a mouse model of Alzheimer's diseas. Hum Mol Genet. 2015; 24: 5388-403.

Xiao X, Zhao XT, Xu LC, Yue LP, Liu FY, Cai J, Liao FF, Kong JG, Xing GG, Yi M, Wan Y. Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats. Pain. 2015; 156: 597-608.

Fang D, Kong LY, Cai J, Li S, Liu XD, Han JS, Xing GG. Interleukin-6- mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model. Pain. 2015; 156: 1124-1144.

Liu J, Du J, Yang Y, Wang Y. Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia. Exp Neurol. 2015;273:253-262.

Qi C, Wang XJ, Ge FF, Li YJ, Shen F, Wang JK, Cui CL. mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling. Addict Biol. 2015; 20:927-40.

Ding X, Cai J, Li S, Liu XD, Wan Y, Xing GG. BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation. Neurobiol Dis. 2015; 73:428-51.

Lv XF, Sun LL, Cui CL, Han JS. NAc shell Arc/Arg3.1 protein mediates reconsolidation of morphine CPP by increase GluR1 cell surface expression: activation of ERK coupled CREB is required. Int J Neuropsychopharmacol. 2015;18. pii: pyv030.

Tong Y, Yang H, Tian X, Wang H, Zhou T, Zhang S, Yu J, Zhang T, Fan D, Guo X, Tabira T, Kong F, Chen Z, Xiao W, Chui DH. High Manganese, A Risk for Alzheimer’s disease: high manganese induces amyloid-beta related cognitive impairment. J Alzheimers Dis. 2014;42:865-78.

Jiang H, Fang D, Kong LY, Jin ZR, Cai J, Kang XJ, Wan Y, Xing GG. Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats. Mol Brain. 2014; 7: 72.

Qi C, Liu SM, Qin R, Zhang Y, Wang GQ, Shang YF, Wang Y, Liang J. Coordinated regulation of dendrite arborization by epigenetic factors CDYL and EZH2. J Neurosci. 2014; 34:4494-508.

Wang H, Sun M, Yang H, Tian X, Tong Y, Zhou T, Zhang T, Fu Y, Guo X, Fan D, Yu A, Fan M, Wu X, Xiao W, Chui DH. Hypoxia-inducible factor-1α mediates up-regulation of neprilysin by histone deacetylase-1 under hypoxia condition in neuroblastoma cells. J Neurochem. 2014;131:4-11.

Wang K, Xiang XH , Qiao N, Qi JY, Lin LB, Zhang R, Shou XJ, Ping XJ, Han JS, Han JD, Zhao GP, Cui CL. Genome wide analysis of rat periaqueductal gray-dorsal horn reveals time-, region- and frequency-specific mRNA expression changes in response to electro- acupuncture stimulation. Sci Rep. 2014;4:6713.

Li Y, Hu F, Chen HJ, Du YJ, Xie ZY, Zhang Y, Wang J, Wang Y. LIMK- dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Sci Signal. 2014; 7:ra61.

Sun LL, Hu L, Li YJ, Cui CL. Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal. Brain Struct Funct. 2014;219:1755-71.

Wang N, Su P, Zhang Y, Lu J, Xing BM, Kang K, Li WQ, Wang Y. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacology. 2014; 39: 1290-301.

Zhang YK, Huang ZJ, Liu S, Liu YP, Song AA, Song XJ. WNT signaling underlies the pathogenesis of neuropathic pain in rodents. J Clin Invest. 2013; 123: 2268-86.

Li Z, Wang J, Chen L, Zhang M, Wan Y. Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats. PLoS One. 2013; 8: e70921.

Zhang H, Chen X, Zhang C, Zhang R, Lao L, Wan Y, Yi M. Comparison of electroacupuncture in restrained and unrestrained rat models. Evid Based Complement Alternat Med. 2013;2013:404956.

Wang J, Wang J, Li X, Li D, Li XL, Han JS, Wan Y. Modulation of brain electroencephalography oscillations by electroacupuncture in a rat model of postincisional pain. Evid Based Complement Alternat Med. 2013; 2013: 160357.

Liu X, Lu M, Tang L, Zhang N, Chui D, Fan D. ATXN2 CAG repeat expansions increase the risk for Chinese patients with amyotrophic lateral sclerosis. Neurobiol Aging. 2013;34:2236.e5-8.

Zheng Q, Fang D, Liu M, Cai J, Wan Y, Han JS, Xing GG. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain. 2013;154:434-48.

Wang YN, Wang B, Liang M, Han CY, Zhang B, Cai J, Sun W, Xing GG. Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, while up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats. Fertil Steril. 2013; 99:579-87.

Liu M, Yang H, Fang D, Yang JJ, Cai J, Wan Y, Chui DH, Han JS, Xing GG. Up-regulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglion contributes to the bone cancer pain. Pain. 2013;154:1551-68.

Liu J, Liu FY, Tong ZQ, Li ZH, Chen W, Luo WH, Li H, Luo HJ, Tang Y, Tang JM, Cai J, Liao FF, Wan Y. Lysine-specific demethylase 1 (LSD1) in the breast cancer cells contributes to the production of endogenous formaldehyde in metastatic bone cancer pain model of rats. PLoS One. 2013; 8: e58957.

Liu S, Liu YP, Song WB, Song XJ. EphrinB-EphB receptor signaling contributes to bone cancer pain via Toll-like receptor and proinflammatory cytokines in rat spinal cord. Pain. 2013;154:2823-35.

Gao K, Wang CR, Jiang F, Wong AYK, Su N, Jiang JH, Chai RC, Teng J, Chen J, Jiang YW, Yu ACH. Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c-Jun/AP-1 pathway and switch on GFAP expression. Glia. 2013;61:2063-77.

Chai RC, Jiang JH, Wong AYK, Jiang F, Gao K, Vatcher G, Yu ACH. AQP5 is differentially regulated in astrocytes during metabolic and traumatic injuries. Glia 2013; 61:1748-65.

Huang ZJ, Li HC, Cowan AA, Liu S, Zhang YK, Song XJ. Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2. Pain. 2012; 153:1426-37.

Wang KW, Wang Y. Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection? Front Mol Neurosci. 2012;5:39.

Ping X, Ma Y, Li Y, Qi C, Sun X, Lv X, Cui C. Essential role of protein kinase C in morphine-induced rewarding memory. Neuropharmacology. 2012; 62:959-66.

Xing BM, Yang YR, Du JX, Chen HJ, Qi C, Huang ZH, Zhang Y and Wang Y. Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B. J Neurosci. 2012; 32: 14709-21.

Zhu YB, Kang K, Zhang Y, Qi C, Li G, Yin DM and Wang Y. PLD1 negatively regulates dendritic branching. J Neurosci. 2012; 32:7960-9.

Wang K, Zhang R, Xiang XH, He F, Lin LB, Ping XJ, Yu L, Han JS, Zhao GP, Zhang QH, Cui CL. Differences in neural-immune gene expression response in rat spinal dorsal horn correlates with variations in electroacupuncture analgesia. PLoS ONE. 2012; 7 e42331.

Sun M, Zhou T, Zhou L, Chen Q, Yu Y, Yang H, Zhong K, Zhang X, Xu F, Cai S, Yu A, Zhang H, Xiao R, Xiao D, Chui D. Formononetin protects neurons against hypoxia-induced cytotoxicity through upregulation of ADAM10 and sAβPPα. J Alzheimers Dis. 2012;28:795-808.

Yu Y, Zhou L, Sun M, Zhou T, Zhong K, Wang H, Liu Y, Liu X, Xiao R, Ge J, Tu P, Fan DS, Lan Y, Hui C, Chui D. Xylocoside G reduces amyloid-β induced neurotoxicity by inhibiting NF-κB signaling pathway in neuronal cells. J Alzheimers Dis. 2012;30:263-75.

Zhou T, Shun M, Zhou L, Yang H, Zhong K, Zhang X, Zhang H, Fan D, Chui DH. Formononetin could increase soluble-APPα secretion by up-regulating ADAM10 level. Mol Neurodegener. 2012;7 Suppl 1:O10.

Zheng Q, Fang D, Cai J, Wan Y, Han JS, Xing GG. Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain. Mol Pain. 2012;8:24.

Zhang R, Jia MX, Zhang JS, Xu XJ, Shou XJ, Zhang XT, Li L,Li N, Han SP, Han JS. Transcutaneous electrical acupoint stimulation in children with autism and its impact on plasma levels of arginine-vasopressin and oxytocin: A prospective single-blinded controlled study. Res Dev Disabil. 2012; 33:1136-46.

Zuo Y, Wang X, Cui C, Luo F, Yu P, Wang X. Cocaine-induced impulsive choices are accompanied by impairing delay-dependent anticipatory activity in basolateral amygdale. J Cogn Neurosci. 2012;24:196-211.

Yi M, Zhang H, Lao L, Xing GG, Wan Y. Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats. Mol Pain. 2011;7:61.

Yi M, Zhang H. Nociceptive memory in the brain: cortical mechanisms of chronic pain. Nociceptive memory in the brain: cortical mechanisms of chronic pain. J Neurosci. 2011;31:13343-5.

Huang ZJ, Hsu E, Li HC, Rosner AL, Rupert RL, Song XJ. Topical application of compound Ibuprofen suppresses pain by inhibiting sensory neuron hyperexcitability and neuroinflammation in a rat model of intervertebral foramen inflammation. J Pain 2011;12:141-52

Liu S, Liu WT, Liu YP, Dong HL, Henkemeyer M, Song XJ. Blocking EphB1 receptor forward signaling in spinal cord relieves bone cancer pain and rescues analgesic effect of morphine treatment in rodents. Cancer Res. 2011;71:4392-402.

Li HY, Zhang R, Cui CL, Han JS, Wu LZ. Damage of splenic T lymphocyte proliferation and differentiation and its normalization by electroacupuncture in

morphine-dependent mice model. Evid Based Complement Alternat Med. 2011; 2011:424092.

Geng SJ, Liao FF, Dang WH, Ding X, Liu XD, Cai J, Han JS, Wan Y, Xing GG. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Exp Neurol. 2010;222:256-66.

Wang K, Xiang XHHe F, Lin LB, Zhang R, Ping XJ, Han JS, Guo N, Zhang QH, Cui CL, Zhao GP. Transcriptome profiling analysis reveals region-distinctive changes of gene expression in the CNS in response to different moderate restraint stress. J Neurochem. 2010;113:1436-46.

Dong Y, Zhao R, Chen XQ, Yu ACH. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J Neurosci. 2010; 30:7575-86.

Li M, Sun M, Liu Y, Yu J, Yang H, Fan DS, Chui DH. Copper downregulates neprilysin activity through modulation of neprilysin degradation. J Alzheimers Dis. 2010;19:161-9.

Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, LiJF, Zhou Z, Wang KW, Wang Y. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J Neurosci. 2010; 30:7575-86.

Geng SJ, Liao FF, Dang WH, Ding X, Liu XD, Cai J, Han JS, Wan Y, Xing GG. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Exp Neurol. 2010;222:256-66.

Tong Z, Luo W, Wang Y, Yang F, Han Y, Li H, Luo H, Duan B, Xu T, Maoying Q, Tan H, Wang J, Zhao H, Liu F, Wan Y. Tumor tissue-derived formaldehyde and cidic microenvironment synergistically induce bone cancer pain. PLoS ONE. 2010; 5: e10234.

Liang J, Ping XJ, Li YJ, Ma YY, Wu LZ, Han JS, Cui CL. Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: Role of enkephalin in the nucleus accumbens. Neuropharmacology. 2010;58:233-40.

Dong Y, Zhao R, Chen XQ, Yu ACH. 14-3-3γ and neuroglobin are new intrinsic protective factors for cerebral ischemia. Mol Neurobiol. 2010; 41(2-3):218-31.

Liu WT, Han Y, Liu YP, Song AA, Barnes B, Song XJ. Spinal matrix metalloproteinase-9 contributes to physical dependence on morphine in mice. J Neurosci. 2010; 30:7613-23.