Yun WANG, PhD
Baya Distinguished Professor
Associate Dean of the Institute of Advanced Clinical Medicine and vice director of Neuroscience Research Institute, Peking University
 

Contact information:

Address: 38 Xue-Yuan Road, Beijing 100191

Phone: (010)-82801119 (O)

Fax: (010)-82801119

Email: wangy66@bjmu.edu.cn

 

Education:

1984-1989 Bachelor's Degree, Jiangxi Medical College, 

1989-1992 Master's Degree Program, Beijing Medical University

1993-1996 Doctoral Program in Neuroscience, Beijing Medical University

 

Professional Experience:

2023-               Associate Dean of the Institute of Advanced Clinical Medicine

2013-2023       Associate Dean of the School of Basic Medical Sciences and vice director of Neuroscience Research Institute

2004-present  Professor and vice director of Neuroscience Research Institute, Peking University

1999-2004      Associate professor, Neuroscience Research Institute, Peking University

2000-2002      NCI, NIH, USA. Visiting scientist

1992-1999      Lecturer, Neuroscience Research Institute, Beijing Medical University

 

Awards: 

2107 Wuzhou Women's Science and Technology Award from Chinese Women Doctors Association

2011 “Hsiang-Tung Chang Outstanding Young Scientist Prize” from Hsiang-Tung Chang Foundation

2010 National Natural Science Funds for Distinguished Young Scholar

2001 “The Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions” from Ministry of Education of China

 

Professional membership:

2023-2027  1^st vice president of Federation of the Asian and Oceanian Physiological Societies, FAOPS

2023-2026 26^th President of the Chinese Association for Physiological Science

2023-2025 Board member of general assembly of IUPS

2019-2023 Executive Council Member of Chinese Society for Neurosciences

2019-2021 Council of Asian/Pacific Regional Committee, APRC, International Brain Research Organization, IBRO

2019-2023 Council of Federation of the Asian and Oceanian Physiological Societies, FAOPS

2018-2022 25^th President of the Chinese Association for Physiological Science

2014-2018 Vice President and Secretary General of the Chinese Association for Physiological Sciences

2010-2018 Secretary General of the Chinese Association for Physiological Sciences

2007- Secretary General of China Branch of International Neuropeptide Society

2010-2013 Vice chair of the Basic Research Branch of the Chinese Association for the Study of Pain

2011-2014 Council Member of Chinese Society for Neurosciences

 

Experience for Organizing International Conference：

2022 President of 39^th IUPS Congress (Virtual)

2021 President of 2021 Annual Conference f the Chinese Association for Physiological Sciences (Virtual))

2020 President of 2019 Annual Conference f the Chinese Association for Physiological Sciences (Virtual))

2019 President of Frontiers in Physiology Beijing Forum-2019

2019 President of 2019 Annual Conference f the Chinese Association for Physiological Sciences

2018 Secretary General Secretary General of 25^th Congress of the Chinese Association for Physiological Sciences 

2016 Secretary General of International Conference of Physiological Sciences 2016

2014 Secretary General of 24^th Congress of the Chinese Association for Physiological Sciences

2012 Secretary General of International Conference of Physiological Sciences 2012

2011 Secretary General of 9th International Association for the Study of Pain Research Symposium

2008 Secretariat of The Beijing Joint Conference of Physiological Sciences 2008

2007 Secretary General of The 1st Chinese International Bioactive Neuropeptide Conference

2004 Secretariat of The 1st Conference of Chinese Physiological Scientists

2000 Secretariat of the 4th East-West Pain Conference

 

Research Interests:

Currently, we are interested in neural signal transduction. We use multidisciplinary approaches, integrating molecular biology, genetics, neurobiology, biochemistry, imaging, electrophysiology and behavior to confine our research in the following two areas: 
 

1. To study the possible roles of signal transduction pathway in pain and pain modulation:

We will use the chronic pathological pain models to study the plasticity of neurons of pain transduction pathway. We will focus on protein kinase, the key molecule in the signal transduction pathway, to identify the specific signals associated with chronic pain, pain related negative emotion and memory, to find new analgesic target or analgesics and provide new insight for solving the problem of pain relief in clinic.

 

2. To study mechanisms underlying neural development, injury and repair:

We will use primary culture cells and animal models to identify the key molecules involved in process of neural polarity, migration, dendritic arborization, synaptic formation and pruning and the process of repair post peripheral nerve injury (sharing similar mechanisms of neural development) and neuronal ischemic injury/anti-injury. We aim to elucidate the pathological mechanisms underlying congenital diseases of neural development and acquired neural injury like mechanical and ischemic injury and try to find key molecules, design potential intervention strategies, provide new methods for the treatment of neuropsychiatric diseases.

 

Selected Publications：（CA: Corresponding author）：

1.  Lyu TJ, Ma J, Zhang XY, Xie GG, Liu C, Du J, Xu YN, Yang DC, Cen C, Wang MY, Lyu NY, Wang Y^CA, Zhang HQCA. Deficiency of FRMD5 results in neurodevelopmental dysfunction and autistic-like behavior in mice. Mol Psychiatry. 2024 Jan 16. doi: 10.1038/s41380-024-02407-w. Epub ahead of print. PMID: 38228891.

2. Huan-Yu Zheng, Yu-Meng Chen, Yao Xu, Cheng CenCA, Yun Wang^CA. Excitatory neurons in the lateral parabrachial nucleus mediate the interruptive effect of inflammatory pain on a sustained attention task. J Transl Med. 2023 Dec 10;21(1):897. doi: 10.1186/s12967-023-04778-0.

3. Chen Q*, Zhang XY*, Wang YP*, Fu YJ*, Cao F, Xu YN, Kong JG, Tian NX, Xu Y, Wang Y^CA. Unveiling adcyap1 as a protective factor linking pain and nerve regeneration through single-cell RNA sequencing of rat dorsal root ganglion neurons. BMC Biol. 2023 Oct 25;21(1):235.

4. Kong JG, Mei Z, Zhang Y, Xu LZ, Zhang JCA, Wang Y^CA. CDYL knockdown reduces glioma development through an antitumor immune response in the tumor microenvironment. Cancer Lett. 2023 Jul 28;567:216265. doi: 10.1016/j.canlet.2023.216265. Epub 2023 Jun 9.PMID: 37302564.

5.Sun ZW, Waybright JM, Beldar S, Chen L, Foley CA, Norris-Drouin JL, Lyu TJ, Dong A, Min J, Wang YP, James LI^CA, Wang Y^CA. Cdyl deficiency brakes neuronal excitability and nociception through promoting Kcnb1 transcription in peripheral sensory neurons. Adv Sci (Weinh). 2022 Feb 4:e2104317. doi: 10.1002/advs.202104317. Online ahead of print. PMID: 35119221.

6. Wang F, Yin XS, Lu J, Cen C^CA and Wang Y^CA. Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory. Sci Signal. 2022 Feb;15(719):eabd0033. doi: 10.1126/scisignal.abd0033. Epub 2022 Feb 1.

7. Liu L, Liu TT, Xie GG, Zhu XQ, Wang Y^CA. Ubiquitin ligase TRIM32 promotes dendrite arborization by mediating degradation of the epigenetic factor CDYL. FASEB J. 2022 Jan;36(1):e22087. doi: 10.1096/fj.202100031RR.PMID: 34888944 

8. Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S^CA, Wang Y^CA, Min J^CA. Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol. 2020 Jul 16;27(7):827-838.e7. doi: 10.1016/j.chembiol.2020.05.007. Epub 2020 May 28.

9. Liu H, Su D, Liu L, Chen L, Zhao Y, Chan SO, Zhang W, Wang Y^CA, Wang J^CA. Identification of a new functional domain of Nogo-A that promotes inflammatory pain and inhibits neurite growth through binding to NgR1. FASEB J. 2020 Jun 29. doi: 10.1096/fj.202000377R. Online ahead of print.

10. Huang S, Zheng C, Xie G, Song Z, Wang P, Bai Y, Chen D, Zhang Y, Lv P, Liang W, She S, Li Q, Liu Z, Wang Y, Xing GG^CA, Wang Y^CA. FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice. Mol Psychiatry. 2020 Apr 21. doi: 10.1038/s41380-020-0720-x. Online ahead of print.

11. Yin XS, Yang JY, Cao S, Wang Y^CA. Failure of Placebo Analgesia Model in Rats with Inflammatory Pain. Neurosci Bull. 2020 Feb;36(2):121-133. doi: 10.1007/s12264-019-00420-6. Epub 2019 Aug 21.

12. Li WQ, Luo LD, Hu ZW, Lyu TJ, Cen C, Wang Y^CA. PLD1 promotes dendritic spine morphogenesis via activating PKD1. Mol Cell Neurosci. 2019 Sep;99:103394. doi: 10.1016/j.mcn.2019.103394. Epub 2019 Jul 26.

13. Liu J, Du J, Wang Y^CA. CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2. Sci Signal. 2019 Jun 11;12(585). pii: eaaw2040. doi: 10.1126/scisignal.aaw2040.

14. Xu Y, Tian NX, Bai QY, Chen Q, Sun XH, Wang Y^CA. Gait Assessment of Pain and Analgesics: Comparison of the DigiGait^TM and CatWalk^TM Gait Imaging Systems. Neurosci Bull. 2019 Jun;35(3):401-418. doi: 10.1007/s12264-018-00331-y. Epub 2019 Jan 18.

15. Hu F, Liu HC, Su DQ, Chen HJ, Chan SO, Wang Y^CA, Wang J^CA. Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron. FASEB J . 2019 Jan;33(1):668-682. doi: 10.1096/fj.201800382RR. Epub 2018 Jul 19. PMID:30024789.

16. Guo YP, Zhi YR, Liu TT, Wang Y, Zhang Y^CA. Global Gene Knockout of Kcnip3 Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats. Front Mol Neurosci. 2019 Jan 25;12:5. doi: 10.3389/fnmol.2019.00005. eCollection 2019. PMID: 30740043

17. Duo L, Hu L, Tian N, Cheng G, Wang H, Lin Z, Wang Y^CA, Yang Y^CA. TRPV1 gain-of-function mutation impairs pain and itch sensations in mice. Mol Pain. 2018 Jan-Dec;14:1744806918762031. doi: 10.1177/1744806918762031. Epub 2018 Feb 9.

18. Tian NX, Xu Y, Yang JY, Li L, Sun XH, Wang Y^CA and Zhang Y^CA. KChIP3 N-terminal 31-50 fragment mediates its association with TRPV1 and alleviates inflammatory hyperalgesia in rats. J Neurosci.   2018 Jan 15. pii: 2242-17. doi: 10.1523/JNEUROSCI.2242-17.2018. [Epub ahead of print] PMID: 29335353.

19. Cen C, Luo LD, Li WQ, Li G, Tian NX, Zheng G, Yin DM, Zou YM, Wang Y^CA. PKD1 promotes functional synapse formation coordinated with N-cadherin in hippocampus. J Neurosci. 2018 Jan 3; 38(1):183-199.

20. Luo LD, Li G, Wang Y^CA. PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage. Scientific Reports.  2017 Jul 20; 7(1):6035. doi: 10.1038/s41598-017-06121-2.

21. Huang M, Cheng G, Tan H, Qin R, Zou Y, Wang Y^CA, Zhang Y^CA.Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Exp Neurol. 2017 Sep;295:66-76. doi: 10.1016/j.expneurol.2017.05.001. Epub 2017 May 4.

22. Qin R, Cao S, Lyu T, Qi C, Zhang W, Wang Y^CA.CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy. Cell Rep. 2017 Jan 10;18(2):380-390. doi: 10.1016/j.celrep.2016.12.043.

23. Zhang C, Lu J, Liu B, Cui Q^CA, Wang Y^CA. Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease. Aging (Albany NY). 2016 Feb;8(2):272-90.

24. Liu J, Du J, Yang Y, Wang Y^CA. Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia. Exp Neurol. 2015 Nov;273:253-62. doi: 10.1016/j.expneurol.2015.09.005. Epub 2015 Sep 12.

25. Wang Y. FXYD2: a promising drug target for inflammatory mechanical pain therapy. Science Bulletin 2015, 60(9):896-898. (Research Highlight )

26. Wang GQ, Cen C, Cao S, Li C,Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LP^CA and Wang Y^CA. Deactivation of excitatory neurons in the contralateral prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun. 2015, Jul 16; 6: 7660. doi: 10.1038/ncomms8660.

27. Zhang Y, Wang N, Su P, Lu J, Wang Y^CA. Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice. Neurosci Bull. 2014, 30(6):1025-35.

28. Li Y, Hu F, Chen HJ, Du YJ, Xie ZY, Zhang Y, Wang J^CA, Wang Y^CA. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Sci Signal. 2014 Jun 24;7(331):ra61. doi: 10.1126/scisignal.2005353.

29. Wang N, Su P, Zhang Y, Lu J, Xing BM, Kang K, Li WQ, Wang Y^CA. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacol. 2014, 39(5):1290-301.

30. Qi C, Liu SM, Qin R, Zhang Y, Wang GQ, Shang, YF, Wang Y^CA and Liang J^CA. Coordinated Regulation of Dendrite Arborization by Epigenetic Factors CDYL and EZH2. J Neurosci. 2014 March 26;34(13):4494-508.

31. Li G, Wang Y^CA. Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system. Neurosci Bull. 2014 Jun;30(3):497-504. doi: 10.1007/s12264-013-1403-2. Epub 2014 Feb 13.

32. Xing BM, Yang YR, Du JX, Chen HJ, Qi C, Huang ZH, Zhang Y^CA and Wang Y^CA. Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B. J Neurosci. 2012 Oct 17;32(42):14709-21.

33. Zhu YB, Kang K, Zhang Y, Qi C, Li G, Yin DM^CA and Wang Y^CA. PLD1 negatively regulates dendritic branching. J Neurosci. 2012 Jun 6;32 (23):7960-9.

34. Wang KW^CA,Wang Y^CA. Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection? Front Mol Neurosci. (Invited review) 2012 Mar 15;5:39.

35. Chen HJ, Xie WY, Hu F, Zhang Y, Wang J, Wang Y^CA. Disruption of δ-opioid receptor phosphorylation at Threonine 161 attenuates morphine tolerance in rats with CFA-induced inflammatory hypersensitivity. Neurosci Bull. April 1, 2012, 28(2): 182-192.

36. Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, Li JF, Zhou Z, Wang KW, Wang Y^CA. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J Neurosci. 2010 Jun 2;30(22):7575-86.

37. Xie WY, He Y, Yang YR, Li YF, Kang K, Xing BM, Wang Y^CA. Disruption of cdk5- associated phosphorylation of residue threonine-161 of the delta opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance. J Neurosci. 2009 Mar 18;29(11):3551-64.

38. Yin DM, Huang YH, Zhu YB, Wang Y^CA. Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus. J Neurosci. 2008 Aug 27;28(35):8832-43.

39. Zhu HH, Yang YR, Zhang H, Han Y, Li YF, Zhang Y, Yin DM, He QH, Zhao ZQ, Blumberg PM, Han JS, Wang Y^CA. Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity. Pain. 2008 Jul 31;137(3):574-88.

40. He Y, Li HL, Xie WY, Yang CZ, Yu AC, Wang Y^CA. The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte. Glia. 2007 Apr 15;55(6):573-83.

41. Yang YR, He Y, Zhang Y, Li Y, Li YF, Han Y, Zhu HH, Wang Y^CA. Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia. Pain. 2007 Jan; 127(1-2):109-20.

42. Wang Y^CA, Kedei N, Wang M, Wang QJ, Huppler AR, Toth A, Tran R, Blumberg PM. The interaction between PKCmu and vanilloid receptor type 1. J Biol Chem. 2004 Dec 17;279(51):53674-82.

43. Wang Y, Xie WY, He Y, Wang M, Yang YR, Zhang Y, Yin DM, Jordan-Sciutto KL, Han JS, Wang Y^CA. Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist. Exp Neurol. 2006 Dec;202(2):313-23.

44. Wang Y^CA, Zhang Y, Wang W, Cao Y, Han JS. Effects of synchronous or asynchronous electroacupuncture stimulation with low versus high frequency on spinal opioid release and tail flick nociception. Exp Neurol. 2005 Mar; 192 (1):156-62.

45. Sun RH, Wang HC, Wan Y, Jing Z, Luo F, Han JS,and Wang Y^CA. Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated. Exp Neurol. 2004 May;187(1):23-9.

46. Wang Y^CA. The functional regulation of TRPV1 and its role in pain sensitization. Neurochem Res. 2008 Oct;33(10):2008-12. (review)

47. Li Y, Zhang Y, Han JS, Wang Y^CA. Distinct responses of DREAM to electroacupuncture stimulation with different frequency under physiological and inflammatory conditions in rats. Neurochem Res. 2008 Oct;33(10):2070-7.

48. Zhang Y, Li Y, Yang YR, Zhu HH, Han JS, Wang Y^CA. Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain. Neurochem Res. 2007, 32(9):1592-9.

49. Lazar J, Braun DC, Toth A, Wang Y, Pearce LV, Pavlyukovets VA, Blumberg PM, Garfield SH, Wincovitch S, Choi HK, Lee J. Kinetics of penetration influence the apparent potency of vanilloids on TRPV1. Mol Pharmacol. 2006 Apr;69(4):1166-73.

50. Zhang Y, Xiang B, Li YM, Wang Y, Wang X, Wang YN, Wu LL, Yu GY. Expression and characteristics of vanilloid receptor 1 in the rabbit submandibular gland. Biochem Biophys Res Commun. 2006 Jun 23;345(1):467-73.

51. Toth A, Wang Y, Kedei N, Tran R, Pearce LV, Kang SU, Jin MK, Choi HK, Lee J, Blumberg PM. Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. Life Sci. 2005 May 6; 76(25):2921-32.

52. Lee J, Jin MK, Kang SU, Kim SY, Lee J, Shin M, Hwang J, Cho S, Choi YS, Choi HK, Kim SE, Suh YG, Lee YS, Kim YH, Ha HJ, Toth A, Pearce LV, Tran R, Szabo T, Welter JD, Lundberg DJ, Wang Y, Lazar J, Pavlyukovets VA, Morgan MA, Blumberg PM. Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists. Bioorg Med Chem Lett .  2005 Sep 15;15(18):4143-50.

53. Lee J, Kang SU, Kil MJ, Shin M, Lim JO, Choi HK, Jin MK, Kim SY, Kim SE, Lee YS, Min KH, Kim YH, Ha HJ, Tran R, Welter JD, Wang Y, Szabo T, Pearce LV, Lundberg DJ, Toth A, Pavlyukovets VA, Morgan MA, Blumberg PM. Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists. Bioorg Med Chem L ett.  2005 Sep 15;15(18):4136-42.

54. Lee J, Kang SU, Lim JO, Choi HK, Jin MK, Toth A, Pearce LV, Tran R, Wang Y, Szabo T, Blumberg PM. N-[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure–activity relationships for the ‘C-Region’. Bioorg Med Chem. 2004 Jan 15;12(2):371-85.

55. Lee J, Kim SY, Lee J, Kang M, Kil MJ, Choi HK, Jin MK,Wang Y, Toth A, Pearce LV, Lundberg DJ, Tran R, Blumberg PM. Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism. Bioorg Med Chem. 2004 Jul 1;12(13):3411-20.

56. Lee J, Kang SU, Choi HK, Lee J, Lim JO, Kil MJ, Jin MK, Kim KP, Sung JH, Chung SJ, Ha HJ, Kim YH, Pearce LV, Tran R, Lundberg DJ, Wang Y, Toth A, Blumberg PM. Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity. Bioorg Med Chem Lett. 2004 May 3;14(9):2291-7.

57. Tang XQ, Wang Y, Huang ZH, Han JS, Wan Y. Adenovirus-mediated GDNF ameliorates corticospinal neuronal atrophy and motor function deficits in rats with spinal cord injury. NeuroReport. 2004 Mar 1;15(3):425-9.

58. Wang Y, Toth A, Tran R, Szabo T, Welter JD, Blumberg PM, Lee J, Kang SU, Lim JO, Lee J.  High affinity partial agonists of vanilloid receptor. Mol Pharmacol. 2003 Aug;64(2):325-33.

59. Wang Y, Szabo T, Welter JD, Toth A, Tran R, Lee J, Kang SU, Suh YG, Blumberg PM, Lee J.  High affinity antagonists of the vanilloid receptor. Mol Pharmacol. 2002 Oct;62(4):947-56.

60. Fang M, Wang Y, He QH, Sun YX, Deng LB, Wang XM, Han JS. Glial cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model. Neuroscience. 2003;117(3):503-12.

61. Tóth A, Kedei N, Wang Y, Blumberg PM. Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat. Life Sci. 2003 Jun 13;73(4):487-98.

62. Lee J, Lee J, Kang M, Shin M, Kim JM, Kang SU, Lim JO, Choi HK, Suh YG, Park HG, Oh U, Kim HD, Park YH, Ha HJ, Kim YH, Toth A, Wang Y, Tran R, Pearce LV, Lundberg DJ, Blumberg PM. N-(3-Acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl] thiourea Analogues: Novel Potent and High Affinity Antagonists and Partial Antagonists of the Vanilloid Receptor. J Med Chem. 2003 Jul 3;46(14):3116-26.

63. Tóth A, Kedei N, Szabó T, Wang Y, Blumberg PM. Thapsigargin binds to and inhibits the cloned vanilloid receptor-1. Biochem Biophys Res Commun. 2002 May 3;293(2):777-82.

64. Huang C, Wang Y, Han JS, Wan Y. Characteristics of electroacupuncture-induced analgesia in mice: variation with strain, frequency, intensity and opioid involvement. Brain Res. 2002 Jul 26;945(1):20-5.

65. Wang Y, Wang XM, Han JS. Discrimination between peptide and non-peptide opioid agonists on the transcription of opioid receptors in two cell lines. Life Sci . 2001 May 4;68(24):2731-40.

66. Chen ZW, Yang K,Wang Y^CA, Han JS. The metabolic evidence of synergistic interaction between DAMGO and DPDPE on undifferentiated SH-SY5Y cells. NeuroReport. 2001 Mar 26;12(4):845-9.

67. Chen ZW, Yang K,Wang Y^CA, Han JS. The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen2, D-Pen5] enkephalin on differentiated SH-SY5Y cells in humans. Neurosci Lett. 2001 Feb 9;298(3):199-202.

68. Sun R, Wang Y^CA, Zhao CS, Chang JK, Han JS. Changes in Brain content of   nocicepin/orphanin FQ and endomorphin 2 in a rat model of neuropathic pain. Neurosci Lett. 2001 Sep 21;311(1):13-6.

69. Tang XQ, Wang Y, Han JS, Wan Y. Adenovirus-mediated GDNF protects cultured motoneurons from glutamate injury. Neuroreport. 2001 Oct 8;12(14):3073-6.

70. Sun RQ, Zhao CS, Wang HJ, Jing Z, Wang W, Yang K,Wang Y, Chang JK, Han JS. Nocistatin, a peptide reversing acute and chronic morphine tolerance. Neuroreport. 2001 Jun 13;12(8):1789-92.

71. Huang C, Wang Y^CA, Chang JK, Han JS. Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electroacupuncture stimulation. Neurosci Lett . 2000 Nov 24;294(3):159-62.

72. Wang Y, Huang C, Cao Y, Han JS. Repeated administration of low dose ketamine for the treatment of monoarthritic pain in rat. Life Sci . 2000 Jun 8;67(3):261-7.

73. Fang M, Wang Y, Liu HX, Liu XS, Han JS. Decreased GDNF expression in dorsal spinal cord of unilateral arthritic rat. NeuroReport. 2000 Mar 20;11(4):737-41.

74. Zhao CS, Li BS, Zhao GY, Liu HX, Luo F, Wang Y, Tian JH, Chang JK, Han JS. Nocistatin reverses the effect of orphanin FQ/nociceptin in antagonizing morphine analgesia .NeuroReport. 1999 Feb 5;10(2):297-9.

75. Han Z, Jiang YH, Wan Y, Wang Y, Chang JK, Han JS. Endomorphin-1 mediates 2 Hz but not 100 Hz electroacupuncture analgesia in the rat. Neurosci Lett. 1999 Oct 22;274(2):75-8.

 

Editing and Writing experience:

1. Neurological and Mental Diseases (Second Edition) (Textbook of the 14th five year plan of the National Health Commission and textbook of organ system integration in national colleges and universities) Jianqun Yan and other editors. People's Health Publishing House, Beijing, October 2021, ISBN 978-7-117-31507-4. Yun Wang, Chapter 3, neurophysiology.

2. The Deputy editor in chief of Fundamentals of Disease., Chapter 2 neuroendocrine mechanism of diseases and Chapter 16 neurodegenerative diseases (Textbook of the 13th five year plan of the National Health Commission, guidance series for the improvement of core competence of specialists, for postgraduates with professional degrees and specialists) People's Health Publishing House, Beijing, November 2021, first edition, ISBN: 978-7-117-31569-2

3. The Chief Editor of "Organ system centered" translation textbook, nervous system - basic and clinical (Second Edition), main translation, Peking University Medical Press, Beijing, first edition in July 2019, ISBN: 978-7-5659-2002-8.

4. Y Xu and Yun Wang *. Cocaine, Protein Kinase, and Phosphorylation of Neuronal Receptors. In: Victor R. Preedy, editors, The Neuroscience of Cocaine. Academic Press, 2017, pp. 183-194. ISBN: 978-0-12-803750-8. Copyright. 2017 Elsevier Inc. Academic Press.

 5. Pain Science (First Edition), edited by Jisheng Han, Peking University Medical Press, Beijing, February 2012, first edition, ISBN: 978-7-5659-0198-0. Yun Wang, Chapter 9, opioids and opioid receptor system, p78-89. National key books in the Eleventh Five Year Plan.

6. Neurobiology (First Edition), edited by Longchuan Yu, Peking University Press, Beijing, 1st edition, August 2012, ISBN: 978-7-301-21113-7. Ying Zhang, Yun Wang. Chapter 12, Chapter 3, sensory function of nervous system, p287-329. It is suitable for undergraduate and graduate teaching materials in comprehensive universities.

 7. Neuroscience, 3rd Edition, edited by Jisheng Han, Peking University Medical Press, Beijing, January 2009, 3rd Edition, ISBN: 978-7-81116-605-7. Yun Wang, Chapter 24, neuropeptide II: opioid peptides and their receptors, p438-455.

8. Research methodology of analgesics (First Edition), edited by Gengxin Hong, people's Health Publishing House, Beijing, April 2009, first edition, ISBN: 978-7-117-11072-3. Yun Wang, Chapter 3, neurotransmitters, modulation and pain, p37-49.