Jie Zheng (郑杰) Ph.D.

Principal investigator
Neuroscience Research Institute, Peking University
38 Xueyuan Road, Beijing 100191, China
Email: zhengjiie@hsc.pku.edu.cn
Web page: https://www.x-mol.com/groups/zheng_jiie 
 

Academic experience

2020 – present  Assistant Professor (tenure-track), Department of Neurobiology, Peking University.

2020 – 2022     Associate Professor, Department of Pharmacology, Zunyi Medical University.

2017 – 2020     Postdoctoral Fellow, Department of Pathophysiology, Huazhong University of Science and Technology.

2012 – 2017     Ph.D., Department of Neurobiology, Peking University.

2008 – 2012     B.S., Department of Biomedical Engineering, Huazhong University of Science and Technology.

Research interest

Zheng’s laboratory focuses on Alzheimer’s disease (AD), the main cause of dementia in the elderly. His team has been seeking to unveil how tau pathology is involved in the onset and progression of AD, and to develop tau-based therapeutic drugs. Besides, Dr. Zheng is also interested in tapping the potential of pro-neurogenic remedies for AD treatment.

Publication

# equal contribution, * corresponding author

(1) Zheng J. Hippocampal neurogenesis and pro-neurogenic therapies for Alzheimer's disease. Animal Model Exp Med. 2022. 5(1):3-14.

(2) Zheng J^#*, Tian N^#, Liu F, Zhang Y, Su J, Gao Y, Deng M, Wei L, Ye J, Li H, Wang JZ*. A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies. Signal Transduct Target Ther. 2021. 6(1):269.

(3) Zheng J, Li Y. Compensation for Neurodegeneration by Hippocampal Neurogenesis in Alzheimer's Disease: Where is the Way? Neurosci Bull. 2021. 37(6):885-888.

(4) Zheng J^#*, Li HL^#, Tian N, Liu F, Wang L, Yin YL, Yue LP, Ma LY, Wan Y, Wang JZ*. Interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing GABAergic transmission. Cell Stem Cell. 2020. 26(3):331-345.e6.

(5) Liu F, Tian Na, Zhang HQ, Li SH, Zhou QZ, Zheng J*, Wang JZ*. GSK-3β activation accelerates early-stage consumption of hippocampal neurogenesis in senescent mice. Theranostics. 2020. 10(21):9674-9685. (Co-corresponding author)

(6) Zheng J, Jiang YY, Ma LY, Liu FY, Cui S, Cai J, Liao FF, Wan Y*, Yi M*. Adult hippocampal neurogenesis along the dorsoventral axis contributes differentially to environmental enrichment combined with voluntary exercise in alleviating chronic inflammatory pain in mice. J Neurosci. 2017. 37(15):4145-4157.

(7) Zheng J, Yi M, Wan Y*. Hippocampal neurogenesis: does it relieve or worsen chronic pain? Pain. 2016. 157(2):506-507.

Note: Zheng’s lab recruits for postdoctoral fellows. Please send CV to zhengjiie@hsc.pku.edu.cn.