姜红博士，助理教授、博士生导师

北京大学基础医学院神经生物系

北京大学神经科学研究所

Email: hong.jiang@hsc.pku.edu.cn

主要研究方向

本课题组主要围绕神经调控代谢为核心研究代谢紊乱对疼痛感觉和睡眠觉醒控制调节的神经环路机制。实验室以脑片膜片钳、神经环路示行追踪、光化学遗传、光纤记录、睡眠EEG/EMG结合单细胞和转录翻译组测序等技术，以疼痛模型、肥胖模型和睡眠紊乱模型为基础，利用多种转基因小鼠和小动物行为学，研究从分子、突触到神经环路各层次的动物在生理和病理状态下的神经生物学机制。

学术经历

2022.03至今           助理教授、独立PI、博士生导师，北京大学神经科学研究所，北京大学基础医学院

2015.02-2022.01    博士后，德国马克思普朗克代谢所，神经代谢部门，合作导师：Jens C. Brüning教授

2008.09-2014.12    博士，神经生物学方向，北京大学医学部，导师：万有教授和邢国刚教授

2003.09-2008.07    学士，临床医学方向，郑州大学医学院

代表性论文（#通讯作者，*第一作者）

1. Y. Wang, S. Fu, J. Mao, K. Cui, Hong Jiang#, Hypocretin: a promising target for the regulation of homeostasis, Frontiers in Neuroscience Volume 19 - 2025 (2025).

2. Chen, Xiangtong, Yutong Wang, Su Fu, You Wan, Jian Mao, Kun Cui, and Hong Jiang#. 2025. The Integrated Function of the Lateral Hypothalamus in Energy Homeostasis, Cells 14, no. 14: 1042

3. S. Izawa, D. Fusca, Hong Jiang, C. Heilinger, A.C. Hausen, F.T. Wunderlich, L. Steuernagel, P. Kloppenburg, J.C. Bruning, Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity, Cell Reports 44(2) (2025) 115277.

4. Hong Jiang#. Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control, Medical Review, vol. 2, no. 5, 2022, pp. 531-540.

5. Hong Jiang*, Jiang-Ping Liu, Ke Xi, Ling-Yu Liu, Ling-Yu Kong, Jie Cai, Si-Qing Cai, Xi-Yuan Han, Jing-Gui Song, Xiao-Mei Yang, You Wan, Guo-Gang Xing. Contribution of AMPA receptor-medi ated LTD in LA/BLA-CeA pathway to comorbid aversive and depressive symptoms in neuropathic pain, the Journal of Neuroscience, 2021, 41(34): 7278-7299

6.Hong Jiang*, Sarah Gallet, Paul Klemm, Pia Scholl, Kat Folz-Donahue, Janine Altmüller, Jens Alber, Christian Heilinger, Christian Kukat, Helge Müller-Fielitz, Sivaraj Sundaram, Markus Schwaninger, Vincent Prevot and Jens C. Brüning. MCH Neurons Regulate Permeability of the Median Eminence Barrier. Neuron. 2020, July 22; 107: 1-14.

7. Hong Jiang*, Jens C. Brüning. Melanin-Concentrating Hormone-Dependent Control of Feeding: When Volume Matters. Cell Metabolism. 2018, July 3; 28(1): 7-8.

8. A. Christine Hausen, Johan Ruud, Hong Jiang, Simon Hess, Hristo Varbanov, Peter Kloppenburg, Jens C. Brüning. Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity. Cell Reports. 2016, 17: 2512–2521

9. Hong Jiang*, Dong Fang, Ling-Yu Kong, Zi-Run Jin, Xue-Jing Kang, Jie Cai, You Wan, Guo-Gang Xing. Sensitization of Neurons in the Central Nucleus of the Amygdala via the Decreased GABAergic Inhibition Contributes to the Development of Neuropathic Pain-Related Anxiety-like Behaviors in Rats. Molecular Brain. 2014, 7: 72.