郑杰

博士，助理教授，博士生导师

北京大学基础医学院神经生物系

联系地址：北京市海淀区学院路38号北京大学医学部医学科技楼北楼502D

Email: zhengjiie@hsc.pku.edu.cn

课题组网页：https://www.x-mol.com/groups/zhengjiie

研究方向

阿尔茨海默病（AD）中的神经退变与新生，目前聚焦于：（1）AD及相关疾病中tau蛋白病变的发生机制与靶向干预，尤其是新型嵌合体药物的设计开发。（2）AD促神经新生治疗。

研究方向

2012年毕业于华中科技大学生物医学工程专业，获工学学士学位；2017年于北京大学获医学神经生物学博士学位，2017-2020年于华中科技大学同济医学院王建枝教授实验室从事博士后研究工作， 2020-2022就职于遵义医科大学基础药理教育部重点实验室，2022年加入北京大学医学部神经生物学系。

代表性文章

(# co-first author, * correspondence)

Sun W#, Yang B#, Zheng H#, Wang Q#, Shi Y, Wang G, Yin W, Wang H, Qi X, Yao Y, Wang J, Cui S, Cui K, Mao J, Xia Y, Deng J, Zhao S, Wang Z, Liu F, Yi M, Ding J, Le W, Li X, Yuan J*, Wan Y*,Zheng J*. Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease. Alzheimers Dement. 2026.22(9):e71784.

Zheng H, Zheng J*. Tau-targeting pharmacological strategies in neurodegenerative disease. Trends Pharmacol Sci. 2026. 47(9): 979-994.  

Li Y#, Wang H#, Zhang D#, Wang S#, Li Z, Li J, Tai S, Tong D, Wang B, Lu D, Yuan S, Sun W, Yang B, Bai C, Wang Q, Ding J, Wang Z, Gao Y, Yu H, Cui K, Liu C, Mao J, Yao Y, Liu F, Wan Y, Yuan J*, Liu X*, Zheng J*. Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer's disease-like pathology in mice. Nat Commun. 2026;17(1):2726.

Qi X#, Yuan S#, Ding J#, Sun W, Shi Y, Xing Y, Liu Z, Yao Y, Fu S, Sun B, Qi X, Xia B, Liu F, Yi M, Mao J, Wan Y*, Zheng J*. Emerging signs of Alzheimer-like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID-19. Aging Cell. 2024 Sep 29:e14352. doi: 10.1111/acel.14352.

Su J#, Xiao Y#, Wei L, Lei H, Sun F, Wang W, Yin J, Xiong R, Li S, Zhang P, Zhou Y, Wang X*, Zheng J*, Wang JZ*. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Sci Bull. 2024. 69(8):1137-1152.

Zheng J#*, Tian N#, Liu F, Zhang Y, Su J, Gao Y, Deng M, Wei L, Ye J, Li H, Wang JZ*. A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies. Signal Transduct Target Ther. 2021. 6(1):269. 

Zheng J#*, Li HL#, Tian N, Liu F, Wang L, Yin YL, Yue LP, Ma LY, Wan Y, Wang JZ*. Interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing GABAergic transmission. Cell Stem Cell. 2020. 26(3):331-345.e6.