郑杰

博士，助理教授，PI，博士生导师

北京大学神经科学研究所，北京大学基础医学院神经生物系

联系地址：北京市海淀区学院路38号北京大学医学部医学科技楼北楼502D

Email: zhengjiie@hsc.pku.edu.cn

课题组网页：https://www.x-mol.com/groups/zhengjiie

学术背景

2022.09至今         北京大学，神经科学研究所，新体制助理教授/副研究员

2020.07-2022.07    遵义医科大学，基础药理教育部重点实验室，副教授

2017.07-2020.07    华中科技大学，病理生理学系，博士后

2012.09-2017.06    北京大学，神经科学研究所，理学博士

2008.09-2012.06    华中科技大学，生物医学工程系，工学学士

研究方向

课题组主要围绕阿尔茨海默病（AD）及相关神经退行性疾病的预防、诊断和治疗开展研究工作：（1）从分子-细胞-神经环路-整体水平，研究AD病理机制，针对其中关键靶点开发治疗药物。目前主要以tau蛋白相关病变为关注重点。（2）探讨通过诱导神经再生治疗AD的相关问题。（3）AD诊断生物标志物发现、风险因素解析。

代表性成果

（^#co-first author，*correspondence）

(1) Qi X^#, Yuan S^#, Ding J^#, Sun W, Shi Y, Xing Y, Liu Z, Yao Y, Fu S, Sun B, Qi X, Xia B, Liu F, Yi M, Mao J, Wan Y*, Zheng J*. Emerging signs of Alzheimer-like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID-19. Aging Cell. 2024 Sep 29:e14352. doi: 10.1111/acel.14352

(2) Xiao Y^#, Wei L^#, Su J^#, Lei H, Sun F, Li M, Li S, Wang X*, Zheng J*, Wang JZ*. A tau dephosphorylation-targeting chimera selectively recruits protein phosphatase-1 to ameliorate Alzheimer's disease and tauopathies. Cell Chem Biol. 2024. 31(10):1787-1799.e6

(3) Su J^#, Xiao Y^#, Wei L, Lei H, Sun F, Wang W, Li S, Wang X*, Zheng J*, Wang JZ*. A new tau dephosphorylation-targeting chimera for the treatment of tauopathies. Acta Pharmacol Sin. 2024. 45(11):2267-2276

(4) Su J^#, Xiao Y^#, Wei L, Lei H, Sun F, Wang W, Yin J, Xiong R, Li S, Zhang P, Zhou Y, Wang X*, Zheng J*, Wang JZ*. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Sci Bull. 2024. 69(8):1137-1152.

(5) Gao Y^#*, Wang YY^#, Lei HY, Xu ZD, Li SH, Yu HT, Xie JZ, Zhang ZT, Liu GP, Zhang Y*, Zheng J*, Wang JZ*. A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau. Transl Neurodegener. 2023. 12(1), 51.

(6) Gao Y^#, Yu H^#, Liu Y, Xu Z, He B, Liu H, Wang Y, Zhang Y, Liang Y, Yang Y, Zheng J*, Wang JZ*. GSK-3β activation mediates apolipoprotein E4-associated cognitive impairment in type 2 diabetes mellitus: A multicenter, cross-sectional study. J Diabetes. 2023. 16(1):e13470.

(7) Shi Y, Wan Y, Zheng J*. Waking up neural stem cells through inhibition of mitochondrial pyruvate import. Brain‐X. 2023. 1(2).e13. Commentary

(8) Zheng J. Hippocampal neurogenesis and pro-neurogenic therapies for Alzheimer's disease. Animal Model Exp Med. 2022. 5(1):3-14. Review (Cover story)

(9) Zheng J^#*, Tian N^#, Liu F, Zhang Y, Su J, Gao Y, Deng M, Wei L, Ye J, Li H, Wang JZ*. A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies. Signal Transduct Target Ther. 2021. 6(1):269.

(10) Zheng J, Li Y. Compensation for Neurodegeneration by Hippocampal Neurogenesis in Alzheimer's Disease: Where is the Way? Neurosci Bull. 2021. 37(6):885-888.

(11) Zheng J^#*, Li HL^#, Tian N, Liu F, Wang L, Yin YL, Yue LP, Ma LY, Wan Y, Wang JZ*. Interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing GABAergic transmission. Cell Stem Cell. 2020. 26(3):331-345.e6.

(12) Liu F, Tian Na, Zhang HQ, Li SH, Zhou QZ, Zheng J*, Wang JZ*. GSK-3β activation accelerates early-stage consumption of hippocampal neurogenesis in senescent mice. Theranostics. 2020. 10(21):9674-9685. (Co-corresponding author)

(13) Zheng J, Jiang YY, Ma LY, Liu FY, Cui S, Cai J, Liao FF, Wan Y*, Yi M*. Adult hippocampal neurogenesis along the dorsoventral axis contributes differentially to environmental enrichment combined with voluntary exercise in alleviating chronic inflammatory pain in mice. J Neurosci. 2017. 37(15):4145-4157.  

(14) Zheng J, Yi M, Wan Y*. Hippocampal neurogenesis: does it relieve or worsen chronic pain? Pain. 2016. 157(2):506-507.

另：本课题组招聘博士后，有生物/医学、化学、人工智能与机器学习等背景的青年博士均可申请。请邮件联系zhengjiie@hsc.pku.edu.cn。