万有教授课题组
基本信息：
万有，博士学位，博士后学历，教授，博士生导师。科技部“973”项目首席科学家。
教育部和卫生部神经科学重点实验室，主任
北京大学神经科学研究所，所长
北京大学神经生物学系，主任
联系方式：100191北京市海淀区学院路38号北京大学神经科学研究所
电话：(010)-82805185
E-mail: ywan@hsc.pku.edu.cn
主要经历：
1985年于河南医科大学医疗系获医学学士学位;1990年于河南医科大学药理教研室获硕士学位，1993年于武汉同济医科大学病生教研室获博士学位，1995原北京医科大学生理教研室博士后出站。1998至2000年美国伊利诺伊大学和新泽西大学访问学者。于北京医科大学和北京大学医学部历任讲师(1996年)、副教授(1997年)和教授(2001)。
研究方向：
采用光遗传学、在体多通道记录与神经计算、胞外电生理、单细胞及脑片膜片钳、分子生物学、细胞生物学、形态学、行为药理学等多种方法，从分子—神经元—神经网络—整体不同层面，研究疼痛慢性化的学习记忆、情绪与认知及其调控机制。
1. 疼痛与镇痛的神经生物学机制
2. 针刺镇痛的神经生物学机制
研究生指导：已指导博士后8人、博士生51人、硕士生12人。
获奖：
(1) 集体奖：国家级神经生物学重点学科、国家级精品课程、国家自然基金委创新群体、教育部创新团队。
(2) 个人奖：国务院政府特殊津贴、国家新世纪百千万人才工程、教育部跨世纪优秀人才计划、北京市教委北京市优秀博士学位论文指导教师，以及北京大学方正奖教金教师优秀奖、北京大学研究生“十佳导师”。
(3) 科研奖：国际疼痛学会疼痛研究杰出奖、中国针灸学会科学技术奖、北京市科学技术奖。
学会任职：
(1) 学会：现任中华医学会疼痛学分会副主任委员、中国神经科学会常务理事、中国针灸学会常务理事、中国针灸学会针刺麻醉与针刺镇痛原理分会副理事长。曾任国际疼痛学会中国分会主席、国务院学位委员会学科评议组（生物学组）成员、国际疼痛学会Committee on Fellowships, Grants and Awards, 北京神经科学会秘书长。
(2) 杂志：现任中国疼痛医学杂志副主编、Neuroscience Bulletin副主编，以及国内外10余种学术刊物编委。
基金项目：
2016.01-2019.12: 国家自然科学基金面上项目“酪氨酸磷酸酶Shp-1调节外周TRPV1受体去磷酸化参与大鼠慢性炎症痛的机制研究”(81571067)
2013.1-2017.12: 科技部重大基础研究计划(“973”)项目“基于临床的针麻镇痛与机体保护机制研究”（2013CB531900，项目首席科学家）
2013.1-2016.12: 国家自然科学基金重点项目“慢性痛发生发展的大脑痛矩阵动态脑功能网络及其特征研究”(81230023)
2012.1-2015.12: 国家自然科学基金面上项目“Ⅰ型胰岛素样生长因子上调辣椒素受体参与骨癌痛的机制研究”(81171042)
2012.1-2012.13: 中国中医科学院针灸研究所开放选题项目“针刺镇痛的神经生物学机制”(ZZ04004)
2011-12-2013.12: 教育部高等学校博士学科点专项科研基金“Ⅰ型胰岛素样生长因子上调辣椒素受体参与骨癌痛的机制研究”(20110001110058).
2011.1-2013.12: 国家自然科学基金面上项目“癌细胞分泌内源性甲醛导致癌症痛及其细胞分子机制研究”(81070893)
2010.1-2012.12: 北京市教育委员会“北京市优秀博士学位论文指导教师－肿瘤细胞分泌的甲醛作用于辣椒素受体(TRPV1)引发骨癌痛”
2007.7-2011.8: 科技部重大基础研究计划(“973”)课题“针麻镇痛中高级中枢痛觉信息调制回路的作用”(2007CB512501)
2006.1-2008.12: 国家自然科学基金面上项目“背根神经节神经元辣椒素受体及其表达的移型参与慢性炎性痛的机制”(30570566)
2005.1-2007.12: 北京市自然科学基金项目“HCN通道参与大鼠慢性神经病理痛的机制”(7052039)
2005.1-2007.12: 国家自然科学基金面上项目“超极化激活环核苷酸门控离子通道参与大鼠慢性神经病理痛的机制”(30470559)
2003.1-2005.12: 教育部2003年度“跨世纪优秀人才培养计划”超极化激活环核苷酸门控离子通道(HCN)在神经病理痛中的作用
2002.1-2004.12: 国家自然科学基金面上项目“d-阿片受体在B10和B6小鼠不同针刺镇痛反应中的作用”(30170319)
2003.1-2003.12: 国家自然科学基金主任基金项目“超极化激活离子通道在大鼠慢性神经源性痛中的作用”(30240059)
2002年度教育部“优秀青年教师资助计划”
2001.9: 教育部留学回国启动基金“d-阿片受体在B10和B6小鼠不同针刺镇痛反应中的作用”
1998.10-2000.8: 美国NIH NIDA/INVEST Fogarty基金“针刺镇痛差异的遗传学机制”
1998.1-2000.12: 国家自然科学基金面上项目“膜片钳结合单细胞PCR研究阿片肽/抗阿片肽的分子机制”(39770241)
1997.1-1999.12: 国家自然科学基金面上项目“腺病毒载体介导的脊髓损伤GDNF基因治疗”(39600150)
1993.12-1995.12: 中国博士后基金“帕金森氏病基因治疗的试验研究”
SCI论文（时间倒序）：
Jie Zheng, Ying-Ying Jiang, Long-Yu Ma, Feng-Yu Liu, Shuang Cui, Jie Cai, Fei-Fei Liao, You Wan*, Ming Yi*. Adult hippocampal neurogenesis along the dorsoventral axis contributes differentially to environmental enrichment combined with voluntary exercise in alleviating chronic inflammatory pain in mice. The Journal of Neuroscience2017 (accepted)
Meng Zhang, Jie Cai, Jia Liu, Meng-Meng Zhou, Honghai Wu, Yanning Hou, Yun-Feng Li, Yuxin Yin, Lemin Zheng, Fei-Fei Liao, Feng-Yu Liu, Ming Yi*, You Wan*. Anxiolytic-like effects of elevated neurosteroids in the hippocampus in neuropathic pain rats with spared nerve injury. Journal of Neurochemistry 2017 (accepted)
Chan Zhang, Rong-Xiang Chen, Yu Zhang, Jie Wang, Feng-Yu Liu, Jie Cai, Fei-Fei Liao, Fu-Qiang Xu, Ming Yi*, You Wan*. Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain. Scientific Reports 2017; 7: 41439. doi: 10.1038/srep41439.
Ming-Jia Li, Ling-Yu Liu, Lin Chen, Jie Cai, You Wan, Guo-Gang Xing*. Chronic stress exacerbates neuropathic pain via the integration of stress-affect related information with nociceptive information in the central nucleus of the amygdala. Pain2017 (accepted)
Yu Zhang, Yingying Jiang, Shan Shao, Chan Zhang, Feng-Yu Liu, You Wan, Ming Yi*. Inhibiting medial septal cholinergic neurons with DREADD alleviated anxiety-like behaviors in mice. Neuroscience Letters2017; 638: 139-144.
Jing Wang, Jing Wang, Guo-Gang Xing, Xiaoli Li*, You Wan*. Enhanced gamma oscillatory activity in rats with chronic inflammatory pain. Frontiers in Neuroscience2016; 10: 489. doi: 10.3389/fnins.2016.00489.
Meng Zhang, Jia Liu, Meng-Meng Zhou, Hong-Hai Wu, Yan-Ning Hou, Yun-Feng Li, Yu-Xin Yin, Le-Min Zheng, Feng-Yu Liu, Ming Yi*, You Wan*. Elevated neurosteroids in the lateral thalamus relieve neuropathic pain in rats with spared nerve injury. Neuroscience Bulletin2016, 32(4):311–322. doi 10.1007/s12264-016-0044-7
Jie Zheng, Ming Yi, You Wan*. Hippocampal neurogenesis: Does it relieve or worsen chronic pain? (Correspondence. Letter to Editor) Pain2016; 157: 506-507.
Xing Liu, Jing Wang, Baoguo Wang*, Ying Hua Wang, Qinglei Teng, Jiaqing Yan, Shuangyan Wang, You Wan*. Effect of transcutaneous acupoint electrical stimulation on propofol sedation: an electroencephalogram analysis of patients undergoing pituitary adenomas resection. BMC Complementary and Alternative Medicine2016 Jan 27; 16(1): 33. doi: 10.1186/s12906-016-1008-1
Xiang-Yao Li, You Wan, Shao-Jun Tang, Yun Guan, Feng Wei, and Daqing Ma. Maladaptive Plasticity and Neuropathic Pain. (Editorial) Neural Plasticity2016; 2016: 4842159. doi: 10.1155/2016/4842159.
Haolin Zhang, Jungang Sun, Chao Wang, Congcong Yu, Weiwei Wang, Meng Zhang, Lixing Lao, Ming Yi*, You Wan*. Randomised controlled trial of contralateral manual acupuncture for the relief of chronic shoulder pain. Acupuncture in Medicine2016 Jun; 34(3): 1164-1170. doi: 10.1136/acupmed-2015-010947.
Juan Wang, Ming Yi, Chan Zhang, Zhijie Bian, You Wan, Rixin Chen, Xiaoli Li. Cortical activities of heat-sensitization responses in suspended moxibustion: an EEG source analysis with sLORETA. Cognitive Neurodynamics2015 Dec; 9(6): 581-588. doi: 10.1007/s11571-015-9349-x.
Juanjuan Wang, Y Zhang, Jie Hou, Xianghao Qian, H Zhang, Zhiling Zhang, M Li, R Wang, K Liao, Y Wang, Zhaoyan Li, Dan Zhong, P Wan, L Dong, Feng-Yu Liu, X Wang, You Wan, Wei Xiao, Weiwei Zhang*. Ube2s regulates Sox2 stability and mouse ES cell maintenance. Cell Death and Differentiation2016 Mar; 23(3): 393-404. doi: 10.1038/cdd.2015.106.
Yufei Mei #, Chun Jiang #, You Wan, Jihui Lv, Jianping Jia, Xiaomin Wang, Xu Yang*, Zhiqian Tong*. Aging-associated formaldehyde-induced norepinephrine deficiency contributes to age-related memory decline. Aging Cell2015 Aug; 14(4):659-668. doi: 10.1111/acel.12345.
Xu Ding, Jie Cai, Song Li, Xiao-Dan Liu, You Wan*, Guo-Gang Xing*. BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation. Neurobiology of Disease2015; 73: 428-451. doi: 10.1016/j.nbd.2014.10.025.
Xing Xiao, Xiao-Tao Zhao, Ling-Chi Xu, Lu-Peng Yue, Feng-Yu Liu, Jie Cai, Fei-Fei Liao, Jin-Ge Kong, Guo-Gang Xing, Ming Yi, You Wan*. Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats. Pain2015 April; 156(4): 597–608. doi: 10.1097/01.j.pain.0000460351.30707.c4.
Xiao-Dan Liu#, Jing-Jing Yang#, Dong Fang, Jie Cai, You Wan*, Guo-Gang Xing*. Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain. PLoS One2014; (12): e114623. doi:10.1371/journal.pone.0114623.
Hong Jiang, Dong Fang, Ling-Yu Kong, Zi-Run Jin, Jie Cai, Xue-Jing Kang, You Wan*, Guo-Gang Xing*. Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats. Molecular Brain2014; 7: 72.
Fei-Fei Liao, Chan Zhang, Zhijie Bian, Dingyi Xie, Mingfei Kang, Xiaoli Li, You Wan, Rixin Chen*, Ming Yi*. Characterizing heat-sensitization phenomena in suspended moxibustion with high-density EEG. Pain Medicine2014; 15(8): 1272-1281. doi: 10.1111/pme.12512.
Yu Zhang, Feng-Yu Liu, You Wan, Ming Yi*. Exacerbation of tonic but not phasic pain by entorhinal cortex lesions. Neuroscience Letters2014; 581: 137-142. doi: 10.1016/j.neulet.2014.05.015.
Fei Yang, Jia Guo, Wei-Liang Sun, Feng-Yu Liu, Jie Cai, Guo-Gang Xing, You Wan*. The induction of long-term potentiation in spinal dorsal horn after peripheral nociceptive stimulation and contribution of spinal TRPV1 in rats. Neuroscience2014; 269: 59–66.
Yan Li, Jie Cai, Ying Han, Xing Xiao, Xiang-Ling Meng, Li Su, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Enhanced function of TRPV1 via up-regulation by insulin-like growth factor-1 in a rat model of bone cancer pain. European Journal of Pain2014; 18(6): 774-784. doi: 10.1002/j.1532-2149.2013.00420.x.
Zheng Li, Jing Wang, Lin Chen, Meng Zhang, You Wan*. Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats. PLoS One2013; 8(8): e70921. doi:10.1371/journal.pone.0070921.
Haolin Zhang, Xiaolong Chen, Chan Zhang, Ruixin Zhang, Li-Xing Lao, You Wan* and Ming Yi*. Comparison of restrained and unrestrained rat models of electro-acupuncture in rats. Evidence-Based Complementary and Alternative Medicine2013; 2013: Article ID 404956. http://dx.doi.org/10.1155/2013/404956.
Jing Wang, Jing Wang, Duan Li, Xiao-Li Li, You Wan*. Modulation of brain electroencephalography oscillations by electro-acupuncture in a rat model of post-incisional pain. Evidence-based Complementary and Alternative Medicine2013; vol 2013, article ID 160357. doi:10.1155/2013/160357.
Jia Liu, Feng-Yu Liu, Zhi-Qian Tong, Zhi-Hua Li, Wen Chen, Wen-Hong Luo, Hui Li, Hong-Jun Luo, Yan Tang, Jun-Min Tang, Jie Cai, Fei-Fei Liao, You Wan*. Lysine-specific demethylase 1 (LSD1) in the breast cancer cells contributes to the production of endogenous formaldehyde in metastatic bone cancer pain model of rats. PLoS One2013; 8(3): e58957. doi: 10.1371/journal.pone.0058957.
Zhiqian Tong, Chanshuai Han, Wenhong Luo, Hui Li, Hongjun Luo, Min Qiang, Tao Su, Beibei Wu, Ying Liu, Xu Yang, You Wan, Dehua Cui*, Rongqiao He*. Aging-associated excess formaldehyde leads to spatial memory deficits. Scientific Reports2013; 3: 2045-2322. DOI: 10.1038/srep01807.
Min Liu, Huan Yang, Dong Fang, Jing-Jing Yang, Jie Cai, You Wan, Dehua Chui, Ji-Sheng Han, and Guo-Gang Xing. Up-regulation of P2X3receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglion contributes to the bone cancer pain. Pain2013; 154(9): 1551–1568.
Qin Zheng, Dong Fang, Ming Liu, Jie Cai, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain2013; 154(3): 434-448.
Ye-Nan Chi, Xu Zhang, Jie Cai, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Formaldehyde increases intracellular calcium concentration in primary cultured hippocampal neurons partly through NMDA receptors and T-type calcium channels. Neuroscience Bulletin2012; 28(6): 715-722.
Shenglan Wang, Yi Dai, Kimiko Kobayashi, Wanjun Zhu, Yoko Kogure, Hiroki Yamanaka, You Wan, Wensheng Zhang and Koichi Noguchi*. Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase dependent mechanisms, contributes to inflammatory pain. European Journal of Neuroscience2012; 36(3): 2293-2301.
Wenbing Dai, Wu Jin, Junlin Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, You Wan, Qiang Zhang*. Spatiotemporally controlled co-delivery of anti-vasculature agent and cytotoxic drug by octreotide-modified stealth liposomes. Pharmaceutical Research2012; 29(10): 2902-2911.
Qin Zheng, Dong Fang, Jie Cai, You Wan, Ji-Sheng Han and Guo-Gang Xing*. Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain. Molecular Pain2012; 8: 24.
Ying Han, Yan Li, Xing Xiao, Jia Liu, Xiang-Ling Meng, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in bone cancer pain model of rats. Neuroscience Bulletin2012; 28(2): 165-172.
Chang-Qing Yang, Yan-Yu Wei, Yu-Xin Leng, Chan-Juan Zhong, Yong-Shen Zhang, You Wan, Li-Ping Duan*. Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats. Digestive Diseases and Sciences2012; 57(4): 865-872.
Feng-Yu Liu, Yan-Ni Sun, Fa-Tian Wang, Qian Li, Li Su, Zi-Fang Zhao, Xiang-Ling Meng, Hong Zhao, Xi Wu, Qian Sun, Guo-Gang Xing, You Wan*. Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation. Brain Research2011; 1427: 65-77.
Ming Yi*, Haolin Zhang, Lixing Lao, Guo-Gang Xing, You Wan*. Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats. Molecular Pain2011; 7: 61-67.
Jing Wang, Duan Li, Xiaoli Li, Feng-Yu Liu, Guo-Gang Xing, Jie Cai, You Wan*. Phase – amplitude coupling between theta and gamma oscillations during nociception in rat electroencephalogram. Neuroscience Letters2011; 499: 84-87.
Feng-Yu Liu, Xiao-Xiu Qu, Jie Cai, Fa-Tian Wang, Guo-Gang Xing and You Wan*. Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation. Neuroscience Bulletins2011; 27(1): 1-8.
Zhiqian Tong, Jinling Zhang, Wenhong Luo, Weishan Wang, Fangxu Li, Hui Li, Hongjun Luo, Jing Lu, Jiangning Zhou, You Wan, Rongqiao He*. Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia. Neurobiology of Aging2011; 32(1): 31-41.
Dong Cui, Xianzhen Liu, You Wan, Xiaoli Li*. Estimation of genuine and random synchronization in multivariate neural series. Neural Networks2010; 23: 698-704.
Feng-Yu Liu, Xiao-Xiu Qu, Xu Ding, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain Research2010; 1330: 45-60.
Zhiqian Tong*, Wenhong Luo, Yanqing Wang, Fei Yang, Ying Han, Hui Li, Hongjun Luo, Bo Duan, Tianle Xu, Qiliang Mao-Ying, Huangying Tan, Jun Wang, Hongmei Zhao, Feng-Yu Liu, You Wan*. Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. PLoS One2010; 5(4): e10234. doi:10.1371/journal.pone.0010234
Shan-Jing Geng, Fei-Fei Liao, Wen-Hao Dang, Xu Ding, Xiao-Dan Liu, Jie Cai, Ji-Sheng Han, You Wan, Guo-Gang Xing*. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Experimental Neurology2010; 222(2): 256-266.
Xiao-Xiu Qu, Jie Cai, Ming-Jia Li, Ye-Nan Chi, Fei-Fei Liao, Feng-Yu Liu, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. Experimental Neurology2009; 215(2): 298-307.
Lu Yu, Fei Yang, Hao Luo, Feng-Yu Liu, Ji-Sheng Han, Guo-Gang Xing, You Wan*. The role of TRPV1 in different types of dorsal root ganglion neurons in chronic inflammatory nociception induced by complete Freund’s adjuvant. Molecular Pain2008; 4: 61-70.
Hao Luo, Isabella Shi Xu, Yi Chen, Lu Yu, Fei Yang, Guang-Xin Li, Feng-Yu Liu, Guo-Gang Xing, Yu-Shun Shi, Tan Li, Ji-Sheng Han, You Wan*. Behavioral and electrophysiological evidence for the differential functions of TRPV1 at early and late stages of chronic inflammatory nociception in rats. Neurochemical Research2008; 33(10): 2151-2158.
Cheng Huang, Zhi-Qin Huang, Zhi-Ping Hu, Shao-Zu Jiang, Han-Ting Li, Ji-Sheng Han, You Wan*. Electroacupuncture effects in a rat model of complete Freund's adjuvant-induced inflammatory pain: antinociceptive effects enhanced and tolerance development accelerated. Neurochemical Research2008; 33(10): 2107-2111.
Yu-Qiu Jiang, Guo-Gang Xing, Sheng-Lan Wang, Hui-Yin Tu, Ye-Nan Chi, Jie Li, Feng-Yu Liu, Ji-Sheng Han, You Wan*. Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat. Pain2008; 137: 495-506.
Yue Lu, Yan-Ni Sun, Xi Wu, Qian Sun, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat. Brain Research2008; 1200: 19-26.
Yu-Qiu Jiang, Qian Sun, Hui-Yin Tu, You Wan*. Characteristics of HCN channels and their participation in neuropathic pain. Neurochemical Research2008; 33(10): 1979-1789. (Review)
Albert CH Yu, You Wan, De-Hua Chui, Cai-Lian Cui, Fei Luo, Ke-Wei Wang, Xiao-Min Wang, Yun Wang, Liu-Zhen Wu, Guo-Gang Xing, Ji-Sheng Han. The Neuroscience Research Institute at Peking University: A place for the solution of pain and drug abuse. Cellular Molecular Neurobiology2008; 28(1): 13-19. (Review)
Guo-Gang Xing*, Feng-Yu Liu, Xiao-Xiu Qu, Ji-Sheng Han, You Wan*. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Experimental Neurology2007; 208(2):323-332. (Co-corresponding author. Erratum has been made)
Feng-Yu Liu, Guo-Gang Xing, Xiao-Xiu Qu, Isabella Shi Xu, Ji-Sheng Han, You Wan*. Roles of 5-HT receptor subtypes in the inhibitory effects of 5-HT on the C-fiber responses of the spinal wide dynamic range neurons in rats. The Journal of Pharmacology and Experimental Therapeutics2007; 321(3): 1046-1053.
Fei-Yu Zhang, You Wan, Zhen-Kang Zhang, Alan R Light, Kai-Yuan Fu*. Peripheral formalin injection induces long-lasting increases in cyclooxygenase 1 expression by microglia in the spinal cord. TheJournal of Pain2007; 8(2): 110-117.
Cheng Huang, Zhi-Ping Hu, Shao-Zu Jiang, Han-Ting Li, You Wan*. CCKBreceptor antagonist L365,260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture induced analgesia in mice. Brain Research Bulletin2007; 71(5): 447–451.
Wei Li, You Wan, Ji-Sheng Han, Jiu-Ping Ding, Tao Xu*. Inactivating calcium-activated potassium currents in rat dorsal root ganglia neurons. Progress in Biochemistry and Biophysics2005; 32(5): 408-412.
Xiao Mei Qin, You Wan, Xian Wang*. CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons. Journal of Neuroscience Research2005; 82(1): 51-62.
Byung-Tae Choi, Jun-Hyuk Lee, You Wan, Ji-Sheng Han*. Involvement of ionotropic glutamate receptors in low frequency electroacupuncture analgesia in rats. Neuroscience Letters2005; 377(3): 185-188.
Qian Sun, Guo-Gang Xing, Hui-Yin Tu, Ji-Sheng Han, You Wan*. Inhibition of hyperpolarization-activated current (Ih) suppresses ectopic discharges from injured dorsal root ganglion neurons in a rat model of neuropathic pain. Brain Research2005; 1032(1-2): 63-69.
Qian Sun, Hui-Yin Tu, Guo-Gang Xing, Ji-Sheng Han, You Wan*. Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation. Experimental Neurology2005; 191(1): 128-136.
Cheng Huang, Hua Long, Yu-Shun Shi, Ji-Sheng Han, You Wan*. Ketamine enhances the efficacy to and delays the development of tolerance to electroacupuncture-induced antinociception in rats. Neuroscience Letters2005; 375(2): 138-142.
Xiao-Qing Tang, Yun Wang, Zhi-Hua Huang, Ji-Sheng Han, You Wan*. Adenovirus- mediated delivery of GDNF ameliorates corticospinal neuronal atrophy and motor function deficits in rats with spinal cord injury. NeuroReport2004; 15(3): 425-429.
Hao Luo, Jin Cheng, Ji-Sheng Han, You Wan*. Change of vanilloid receptor 1 expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund's adjuvant in rats. NeuroReport2004; 15(4): 655-658.
Cheng Huang, Han-Ting Li, Yu-Shun Shi, Ji-Sheng Han, You Wan*. Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain. Neuroscience Letters2004; 368(3): 327-331.
Huiyin Tu, Lunbin Deng, Qian Sun, Lei Yao, Ji-Sheng Han, You Wan*. Hyperpolarization-activated, cyclic nucleotide-gated cation channels: roles in the differential electrophysiological properties of rat primary afferent neurons. Journal of Neuroscience Research2004; 76(5): 713-722.
Cheng Huang, Zhi-Ping Hu, Hua Long, Yu-Shun Shi, Ji-Sheng Han, You Wan*. Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture and the involvement of opioids in rat model of chronic inflammatory pain. Brain Research Bulletin2004; 63(2): 99-103.
Rui-Qing Sun, He-Chun Wang, You Wan, Zheng Jing, Fei Luo, Ji-Sheng Han, Yun Wang*. Suppression of neuropathic pain by peripheral electrical stimulation in rats: m-opioid receptor and NMDA receptor implicated. Experimental Neurology2004; 187(1): 23-29.
De-Run Tian, Xiao-Dong Li, Yu-Shun Shi, You Wan, Xiao-Min Wang, Jaw-Kang Chang, Jun Yang, Ji-Sheng Han*. Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats. Peptides2004; 25(12): 2147-2153.
Cheng Huang, Hua Long, Ji-Sheng Han, You Wan*. Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice. Neuroscience Letters2003; 350(2): 93-96.
Cheng Huang, Yun Wang, Ji-Sheng Han, You Wan*. Characteristics of electroacupuncture- induced analgesia in different strains of mice. Brain Research2002; 945(1): 20-25.
William R. Lariviere, Sonya G. Wilson, Tinna M. Laughlin, Anna Kokayeff, Erin E. West, Seetal M. Adhikari, You Wan, Jeffrey S. Mogil*. Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity. Pain2002; 97(1-2): 75-86.
Xiao-Qing Tang, Yun Wang, Ji-Sheng Han, You Wan*. Adenovirus-mediated GDNF protects cultured motoneurons from glutamate injury. NeuroReport 2001; 12(14): 3073-3076.
You Wan, Sonya G. Wilson, Ji-Sheng Han, Jeffrey S. Mogil*. The effect of genotype on sensitivity to electroacupuncture analgesia. Pain2001; 91(1-2): 5-13.
Zou Han, Yu-Hui Jiang, You Wan, Yun Wang, Jaw-Kang Chang, Ji-Sheng Han*. Endomorphin-1 mediates 2 Hz but not 100 Hz electroacupuncture analgesia in the rat. Neuroscience Letters1999; 274: 75-78.
Min Zhang, Qi-Lun Sun, You Wan, Lei Yao, Ying-Xin Yu, Ji-Sheng Han*. OFQ reverses the kappa-opioid receptor-mediated depression of calcium current in the dorsal root ganglion neurons. NeuroReport1998; 9: 2095-2098.
Duan-Duan Ma, Xiao-Min Wang, Xing-Jun Jing, Ji-Ou Wang, Liang Xiong, Hao Song, You Wan, Guo-Heng XuH, Qi-Lun Sun, Hong-Wei Dong, Xin-Hong Wang, Ji-Sheng Han*. GDNF cDNA-enginered NIH 3T3 cells protect primary dopaminergic neurons. Chinese Science Bulletin1997; 42: 1921-1924.