李亦婧副教授简介
李亦婧 博士 副教授
北京大学神经科学研究所
地址：北京市海淀区学院路38号
邮编：100083
电话：010-82801152
Email：liyijing@bjmu.edu.cn
学习和工作经历：
2017-至今：北京大学基础医学院 神经生物学系 副教授
2017-2018：匹兹堡大学 神经科学系 访问学者
2009-2017：北京大学基础医学院 神经生物学系 讲师
2004-2009：北京大学基础医学院 神经生物学系 理学博士
1999-2004：山西医科大学 临床医学系 医学学士
获奖情况：
2019年 北京大学2019年度绿叶生物医药杰出青年学者奖
2017年 北京大学优秀教师
2017年 北京大学医学部优秀教师
2016年 第六届全国医学（医药）院校青年教师教学基本功比赛一等奖第一名，最佳教案奖
2015年 北京高校第九届青年教师教学基本功比赛一等奖，最受学生欢迎奖，最佳教案奖
2015年 北京大学医学部青年岗位能手称号
2014年 首届全国基础医学青年教师讲课比赛特等奖
2014年 北京大学医学部优秀教师
2013年 中华医学科技奖三等奖“经皮穴位电刺激治疗阿片成瘾的疗效及其神经机制”，第四完成人
2013年 北京大学第十三届青年教师教学基本功比赛（医科组）一等奖
2013年 北京大学基础医学院第十三届青年教师授课演示竞赛一等奖
2012年 北京大学基础医学院优秀教师奖
研究方向：
药物成瘾的神经生物学机制。利用电生理学，分子生物学，形态学和行为药理学等方法研究药物成瘾记忆形成和巩固的机制，试图寻找可以清除成瘾记忆的分子靶点。
科研项目：
1. 国家自然基金委面上项目（81771433）：磷酸二酯酶7B介导海马齿状回突触重塑参与成瘾记忆提取的信号通路及microRNA-132的调控作用，项目负责人，2018.01 – 2021.12。
2. 国家自然科学基金青年科学基金（81201031）：多巴胺在吗啡成瘾记忆诱导的vSUB-NAc通路突触易化中的作用及其分子机制研究，项目负责人，2013.01 -2015.12。
3. 教育部新教师基金（20100001120046）：吗啡成瘾记忆再巩固过程中vSUB-NAc兴奋性突触可塑性的研究，项目负责人，2011.01-2013.12。
4. 北京大学医学部新教师科研启动课题：吗啡成瘾记忆再现后腹侧海马下托到伏核兴奋性通路的突触可塑性变化，项目负责人，2009.01-2011.01。
发表论文（#第一作者，*责任作者）：
1. Wang XJ, Hou XY, Huo Y, Wang D, Fan X, Lin XR, Yu WD, Cui CL, Guo JZ*, Li YJ*. Phosphorylated Ser187-SNAP25-modulated hyperfunction of glutamatergic system in the vmPFC mediates depressive-like behaviors in male mice. Neuropharmacology. 2023 Nov 15;239:109691. doi: 10.1016/j.neuropharm.2023.109691.
2. Jia M, Wang XW, Zhang HL, Wang XJ, Ma H, Yang MD, Li YJ*, Cui CL*. MicroRNA-132 is involved in morphine dependence via modifying the structural plasticity of the dentate gyrus neurons in rats. Addict Biol. 2021 Aug 12:e13086.
3. Li YJ#, Ping XJ, Qi C, Shen F, Sun LL, Sun XW, Ge FF, Xing GG, Cui CL*. Re-exposure to morphine-associated context facilitated long-term potentiation in the vSUB-NAc glutamatergic pathway via GluN2B-containing receptor activation. Addict Biol. 2017, 22(2):435-445.
4. Li YJ#, Ping XJ#, Yu P, Liang J, Shen F, Han JS, Cui CL*. Over-expression of the GluN2B subunit in the forebrain facilitates the acquisition of morphine-related positive and aversive memory in rats. Behav Brain Res.2016, 311: 416–424.
5. Sun LL#, Hu L#, Li YJ#, Cui CL*. Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal. Brain Structure and Function. 2014, 219(5): 1755-1771.
6. Li YJ#, Zuo YF, Yu P, Ping XJ, Cui CL*. Role of basolateral amygdala dopamine D2 receptors in impulsive choice in acute cocaine-treated rats. Behav Brain Res. 2015, 287:187-195.
7. Li YJ#，Zhong F，Yu P，Han JS，Cui CL*，Wu LZ*. Electroacupuncture treatment normalized sleep disturbance in morphine withdrawal rats，Evidence-Based Complementary and Alternative Medicine，2011.01.01，2011：361054~361054.
8. Wang ZY, Yue LP, Cui CL*, Liu SL, Wang XW, Li YJ, Ma LY. Top-down control of the medial orbitofrontal cortex to nucleus accumbens core pathway in decisional impulsivity. Brain Struc Funct. 2019; 224(7): 2437-2452.
9. Sun XW, Wang N, Wang XJ, Sun LL, Li YJ, Cui CL*. AMPA Receptor in Ventromedial Prefrontal Cortex Plays Different Roles in the Recent and Remote Retrieval of Morphine-Associated Memory. Neurochem Res. 2019, 44(8):1393-1949.
10. Zhang HL, Jia M, Wang XW, Ye C, Li YJ, Wang N, Elefant F, Ma H, Cui CL*. Dentate gyrus μ-opioid receptor-mediated neurogenic processes are associated with alterations in morphine self-administration. Sci Rep. 2019;9(1):1471.
11.Jia M, Wang XW, Zhang HL, Ye C, Ma H, Yang MD, Li YJ, Cui CL*. MicroRNA-132 in the adult dentate gyrus is involved in opioid addiction via modifying the differentiation of neural stem cells. Neurosci Bull. 2019;35(3):486-496.
12. Ma H, Wang N, Wang XJ, Jia M, Li JY, Cui CL*.Wnt7a in mouse insular cortex contributes to anxiety-like behavior during protracted abstinence from morphine. Neuroscience, 2018, 394:164–176.
13. Wang N, Ge FF,Cui CL*, Li YJ, Sun XW, Sun LL, Wang XJ, Liu SL, Zhang HL, Liu Y, Jia M, Yang MD. Role of glutamatergic projections from the ventral CA1 to infralimbic cortex in context-induced reinstatement of heroin seeking. Neuropsychopharmacology, 2018; 43(6):1373-1384.
14. Ge FF#, Wang N, Cui CL*, Li YJ, Liu Y, Ma YY, Liu SL, Zhang HL, Sun XW Glutamatergic projections from the entorhinal cortex to dorsal dentate gyrus mediate context-Induced reinstatement of heroin seeking. Neuropsychopharmacology. 2017, 42(9):1860-18.
15. Shen F#, Wang XW#, Ge FF, Li YJ, Cui CL*. Essential role of the NO signaling pathway in the hippocampal CA1 in morphine-associated memory depends on glutaminergic receptors. Neuropharmacology. 2016, 102:216-228.
16. Qi C#, Wang XJ#, Ge FF, Li YJ, Shen F, Wang JK, Cui CL*. mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling. Addict Biol. 2015, 20(5):927-940.
17. Shen F#, Wang N, Qi C, Li YJ, Cui CL*. The NO/sGC/PKG signaling pathway in the NAc shell is necessary for the acquisition of morphine-induced place preference. Behav Neurosci. 2014, 128(4):446-459.
18. Shen F#, Li YJ, Shou XJ, Cui CL*. Role of the NO/sGC/PKG signaling pathway of hippocampal CA1 in morphine-induced reward memory. Neurobiol Learn Mem. 2012, (98): 130–138.
19. Xu Y#, Lv XF, Cui CL*, Ge FF, Li YJ, Zhang HL. Essential role of NR2B-containing NMDA receptor–ERK pathway in nucleus accumbens shell in morphine-associated contextual memory. Brain Res Bull. 2012, (89): 22– 30.
20. Liang J#, Ma SS#, Li YJ, Ping XJ, Hu L, Cui CL*. Dynamic changes of tyrosine hydroxylase and dopamine concentrations in the ventral tegmental area-nucleus accumbens projection during the expression of morphine-induced conditioned place preference in rats. Neurochem Res. 2012, 37(7):1482-1489.
21. Ping XJ#, Ma YY#, Li YJ, Qi C, Sun XW, Lv XF, Cui CL*. Essential role of protein kinase C in morphine-induced rewarding memory. Neuropharmacology. 2012, 62(2):959-966.
22. Wang GB#, Wu LZ, Yu Peng, Li YJ, Ping XJ, Cui CL*. Multiple 100 Hz electroacupuncture treatments produced cumulative effect on the suppression of morphine withdrawal syndrome: Central preprodynorphin mRNA and p-CREB implicated. Peptides，2011.4.01，32（4）：713~721.
23. Liang J#, Ping XJ, Li YJ, Ma YY, Wu LZ, Han JS, Cui CL*. Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: role of enkephalin in the nucleus accumbens，Neuropharmacology，2010.1.01，58（1）：233~240.
24. Liang J#, Li YJ, Ping XJ, Yu P, Zuo YF, Wu LZ, Han JS, Cui CL*. The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats，Peptides，2006.12.01，27（12）：3307~3314.